All Phenotypes Hip1r<tm1Tsr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hip1r^tm1Tsr
targeted mutation 1, Theodora S Ross
MGI:3045594

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hip1r^tm1Tsr/Hip1r^tm1Tsr	involves: 129X1/SvJ * C57BL/6	MGI:3045698
cx2	Hip1^tm3Tsr/Hip1^tm3Tsr Hip1r^tm1Tsr/Hip1r^tm1Tsr	involves: 129X1/SvJ	MGI:6719555
cx3	Hip1^tm3Tsr/Hip1^tm3Tsr Hip1r^tm1Tsr/Hip1r^tm1Tsr	involves: 129X1/SvJ * C57BL/6	MGI:3045699
cx4	Hip1^tm3Tsr/Hip1^{tm5.2(HIP1)Tsr} Hip1r^tm1Tsr/Hip1r^tm1Tsr	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:6719556

Allelic Composition	Hip1r^tm1Tsr/Hip1r^tm1Tsr
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hip1r^tm1Tsr mutation (1 available); any Hip1r mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89961 )

• no gross or histological phenotype observable by 12 months of age

• mice were viable, of normal size, and were fertile, producing normal sized litters

Allelic Composition	Hip1^tm3Tsr/Hip1^tm3Tsr Hip1r^tm1Tsr/Hip1r^tm1Tsr
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hip1r^tm1Tsr mutation (1 available); any Hip1r mutation (45 available)
Hip1^tm3Tsr mutation (0 available); any Hip1 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

lordokyphosis ( J:267987 )

• mice exhibit more severe kypholordosis than age-matched than Hip1^{tm5.1(HIP1)Tsr} homozygotes

Allelic Composition	Hip1^tm3Tsr/Hip1^tm3Tsr Hip1r^tm1Tsr/Hip1r^tm1Tsr
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:89961 )

• although not apparent at birth, dwarfism is noticeable by early adulthood

decreased body weight ( J:89961 )

• reduced body mass

mortality/aging

premature death ( J:89961 )

• spontaneous death in two mice at 3 months of age

skeleton

abnormal vertebral column morphology ( J:89961 )

• skeletal disorganization in both thoracic and lumbar spinal regions at 13 weeks of age

abnormal spine curvature ( J:89961 )

• abnormalities in spinal curvature noticeable as early as 2 weeks of age

• all mice exhibit the deformity by weaning

lordokyphosis ( J:89961 )

• dramatically accelerated kypholordosis relative to Hip1^tm3Tsr homozygotes

abnormal vertebral body morphology ( J:89961 )

• vertebral bodies show asymmetry with encroachment of cartilage into areas normally occupied by bone marrow

behavior/neurological

hunched posture ( J:89961 )

Allelic Composition	Hip1^tm3Tsr/Hip1^{tm5.2(HIP1)Tsr} Hip1r^tm1Tsr/Hip1r^tm1Tsr
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:267987 )

N	• mice exhibit no kypholordotic spine, indicating rescue of the spinal phenotype by a single copy of human HIP1

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