All Phenotypes Tfe3<tm1Est> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfe3^tm1Est
targeted mutation 1, Eirikur Steingrimsson
MGI:3044119

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3044232
cx2	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3⁺	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)	MGI:4455029
cx3	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)	MGI:3044416
cx4	Mitf^mi-vga9/Mitf^mi-vga9 Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)	MGI:3044415
cx5	Mitf^Mi/Mitf^Mi Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455022
cx6	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:3044424
cx7	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)	MGI:4455023
cx8	Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3044234
cx9	Tfe3^tm1Est/Tfe3^tm1Est Tfeb^tm1Est/Tfeb⁺	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455030

Allelic Composition	Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas

Allelic Composition	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3⁺
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-ew mutation (1 available); any Mitf mutation (72 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

• osteopetrosis is more severe than in Mitf^mi-ew homozygotes but less severe than in double homozygotes

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89821 )

• mice die within 3 weeks of birth

pigmentation

absent coat pigmentation ( J:89821 )

• mice have a white coat; similar to Mitf^mi-ew/mi-ew mice

craniofacial

delayed tooth eruption ( J:89821 )

growth/size/body

delayed tooth eruption ( J:89821 )

decreased body weight ( J:89821 )

skeleton

delayed tooth eruption ( J:89821 )

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

osteopetrosis ( J:89821 )

• severe

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^mi-ew/mi-ew mice

hematopoietic system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

immune system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

integument

absent coat pigmentation ( J:89821 )

• mice have a white coat; similar to Mitf^mi-ew/mi-ew mice

Allelic Composition	Mitf^mi-vga9/Mitf^mi-vga9 Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-vga9 mutation (1 available); any Mitf mutation (72 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89821 )

• mice die within 3 weeks of birth

pigmentation

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^{mi-vga9/mi-vga9} mice

craniofacial

delayed tooth eruption ( J:89821 )

skeleton

delayed tooth eruption ( J:89821 )

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

osteopetrosis ( J:89821 )

• severe, with complete filling of the bone marrow cavity with bony material

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^{mi-vga9/mi-vga9} mice

hematopoietic system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

immune system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

integument

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^{mi-vga9/mi-vga9} mice

growth/size/body

delayed tooth eruption ( J:89821 )

Allelic Composition	Mitf^Mi/Mitf^Mi Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi mutation (3 available); any Mitf mutation (72 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

immune system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

osteopetrosis ( J:89821 )

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (72 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:89821 )

• most die at 3-4 weeks of age, although some survive to adulthood

pigmentation

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^Mi-wh/Mi-wh mice

growth/size/body

decreased body weight ( J:89821 )

• smaller and more runted than single homozygotes

skeleton

osteopetrosis ( J:89821 )

• bones show signs of osteopetrosis with intermediate extensions of bony trabeculae; less severe than in homozygous Tcfe3^tm1Est mice with other Mitf mutations

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^Mi-wh/Mi-wh mice

integument

absent coat pigmentation ( J:89821 )

• mice are white; similar to Mitf^Mi-wh/Mi-wh mice

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL * DBA) or (involves: 129S1/Sv * C57BL * C57BL/6J * DBA)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

• mice develop osteopetrosis similar to that observed in double Mitf^Mi-wh and Tcfe3^tm1Est mutants

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Allelic Composition	Tfe3^tm1Est/Tfe3^tm1Est Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice were indistinguishable from their wild-type littermates; exhibiting normal eyes, pigment, mast cells, osteoclasts and placentas

Allelic Composition	Tfe3^tm1Est/Tfe3^tm1Est Tfeb^tm1Est/Tfeb⁺
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice exhibit normal eyes, pigment, mast cells, and osteoclasts

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