Analysis Tools
homeostasis/metabolism
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• in male mice
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• in male mice
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• in male mice
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• the number of DEN-induced hepatocellular carcinomas (HCC) in male mice is 5-fold higher than in similarly treated wild-type mice
• the diameter of DEN-induced HCCs in male mice is 2-fold larger than in similarly treated wild-type mice
• DEN-induced HCCs in male mice exhibit neovascularization and macro-vesicular fatty change in the liver unlike in similarly treated wild-type mice
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• CCL4-treated mice exhibit decreased hepatocellular necrosis with no evidence of bridging necrosis or ballooning hepatocytes unlike in wild-type mice
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growth/size/body
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• in DEN-treated mice
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immune system
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• male mice have fewer Kupffer cells in their livers than wild-type mice due to increased apoptosis
• however, no decrease is observed in the spleen and mesenteric lymph nodes
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• in the liver of male mice but not the spleen or mesenteric lymph nodes
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• in the liver
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• more aged mice die of hepatitis than wild-type mice
• aged mice with hepatitis develop hepatocellular carcinoma unlike in wild-type mice
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liver/biliary system
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• male mice have fewer Kupffer cells in their livers than wild-type mice due to increased apoptosis
• however, no decrease is observed in the spleen and mesenteric lymph nodes
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• in DEN-treated mice
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• more aged mice die of hepatitis than wild-type mice
• aged mice with hepatitis develop hepatocellular carcinoma unlike in wild-type mice
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• aged mice with hepatitis develop hepatocellular carcinoma (HCC) unlike in wild-type mice
• HCC are well- or moderately-well differentiated
• HCC invade adjacent hepatic parenchyma while metastasis is infrequent
• HCC exhibit macro-vesicular fatty changes
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neoplasm
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• the number of DEN-induced hepatocellular carcinomas (HCC) in male mice is 5-fold higher than in similarly treated wild-type mice
• the diameter of DEN-induced HCCs in male mice is 2-fold larger than in similarly treated wild-type mice
• DEN-induced HCCs in male mice exhibit neovascularization and macro-vesicular fatty change in the liver unlike in similarly treated wild-type mice
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• aged mice with hepatitis develop hepatocellular carcinoma (HCC) unlike in wild-type mice
• HCC are well- or moderately-well differentiated
• HCC invade adjacent hepatic parenchyma while metastasis is infrequent
• HCC exhibit macro-vesicular fatty changes
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reproductive system
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• mice exhibit preputial abscesses unlike in wild-type mice
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respiratory system
renal/urinary system
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• mice exhibit preputial abscesses unlike in wild-type mice
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cardiovascular system
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• male mice have fewer Kupffer cells in their livers than wild-type mice due to increased apoptosis
• however, no decrease is observed in the spleen and mesenteric lymph nodes
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endocrine/exocrine glands
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• mice exhibit preputial abscesses unlike in wild-type mice
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hematopoietic system
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• male mice have fewer Kupffer cells in their livers than wild-type mice due to increased apoptosis
• however, no decrease is observed in the spleen and mesenteric lymph nodes
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• in the liver of male mice but not the spleen or mesenteric lymph nodes
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integument
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• mice exhibit preputial abscesses unlike in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hepatocellular carcinoma | DOID:684 |
OMIM:114550 |
J:157049 | |
