Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm5Cgn mutation
(0 available);
any
Igh mutation
(43 available)
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hematopoietic system
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• homozygotes display an arrest of B cell development at the B220+CD43+ pro-B cell stage
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• homozygotes lack peripheral B cells
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immune system
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• homozygotes display an arrest of B cell development at the B220+CD43+ pro-B cell stage
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• homozygotes lack peripheral B cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm5Cgn mutation
(0 available);
any
Igh mutation
(43 available)
Tg(CD19-cre/ERT2)1Cgn mutation
(0 available)
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hematopoietic system
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• B cell development is almost exclusively restricted to the generation of B-1 cells
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• mutant mice display a higher percentage of pro-B cells (CD19+CD43+) in the bone marrow relative to wild-type controls
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• mutant mice display an increase in the number of B cells in spleen (4-fold), lymph nodes (2-fold) and peritoneal cavity (2-fold) relative to age-matched wild-type controls
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• >90% of peripheral mutant B cells exhibit a B-1 cell phenotype (CD24intCD38hi)
• no follicular and marginal zone B cells are identified, as most splenic B cells are CD5intCD21loCD23lo
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immune system
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• B cell development is almost exclusively restricted to the generation of B-1 cells
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• mutant mice display a higher percentage of pro-B cells (CD19+CD43+) in the bone marrow relative to wild-type controls
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• mutant mice display an increase in the number of B cells in spleen (4-fold), lymph nodes (2-fold) and peritoneal cavity (2-fold) relative to age-matched wild-type controls
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• >90% of peripheral mutant B cells exhibit a B-1 cell phenotype (CD24intCD38hi)
• no follicular and marginal zone B cells are identified, as most splenic B cells are CD5intCD21loCD23lo
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• non-immunized mutant mice exhibit occasional spontaneous germinal center formation in Peyer's patches
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