Phenotypes associated with this allele

• Allele Symbol: Grip1^tm1Rha
• Allele Name: targeted mutation 1, Ralf H Adams
• Allele ID: MGI:3035931
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grip1^tm1Rha/Grip1^tm1Rha	B6.129-Grip1^tm1Rha	MGI:3035937
hm2	Grip1^tm1Rha/Grip1^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3035936
cx3	Grip1^tm1Rha/Grip1^tm1Rha Grip2^tm1Rha/Grip2^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3035949

Genotype
MGI:3035937

hm1

• Allelic Composition: Grip1^tm1Rha/Grip1^tm1Rha
• Genetic Background: B6.129-Grip1^tm1Rha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:88266 )

N • Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term

limbs/digits/tail

polydactyly ( J:88266 )

• observed in hindlimbs of mice that developed to E16.5

syndactyly ( J:88266 )

• observed in hindlimbs of mice that developed to E16.5

renal/urinary system

abnormal kidney development ( J:88266 )

• at E13.5, unstructured mesenchymal rudiments devoid of metanephric tubules and containing large numbers of apoptotic cells

absent kidney ( J:88266 )

integument

blistering ( J:88266 )

• formation of large subepidermal blisters underneath the epidermal basement membrane of the head, limb, and back skin

• initially transparent when first observed at E11, but blisters became hemorrhagic

• blisters subsided in mice that survived to late gestation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fraser syndrome		DOID:0090001	OMIM:PS219000	J:88266

Genotype
MGI:3035936

hm2

• Allelic Composition: Grip1^tm1Rha/Grip1^tm1Rha
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:88266 )

• Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term

• Background Sensitivity: most mice on a mixed background involving both 129 and C57BL/6 died around E13.5

Genotype
MGI:3035949

cx3

• Allelic Composition: Grip1^tm1Rha/Grip1^tm1Rha; Grip2^tm1Rha/Grip2^tm1Rha
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

limbs/digits/tail

syndactyly ( J:88266 )

• observed in hindlimbs

vision/eye

cryptophthalmos ( J:88266 )

• both unilateral and bilateral cryptophtalmos was observed

integument

integument phenotype ( J:88266 )

N • no externally visible blisters