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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adh5tm1Stam
targeted mutation 1, Jonathan S Stamler
MGI:3033711
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adh5tm1Stam/Adh5tm1Stam B6.129-Adh5tm1Stam MGI:3033876
hm2
 		Adh5tm1Stam/Adh5tm1Stam involves: 129 MGI:5049929
cx3
 		Adh5tm1Stam/Adh5tm1Stam
Nos2tm1Lau/Nos2tm1Lau 		involves: 129 * 129P2/OlaHsd MGI:5049930


Genotype
MGI:3033876
hm1
Allelic
Composition		 Adh5tm1Stam/Adh5tm1Stam
Genetic
Background		 B6.129-Adh5tm1Stam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1Stam mutation (1 available); any Adh5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:88337 )
• 48% mortality from LPS-induced shock compared to 15% of wild-type mice
• higher mortality from bacterial septic shock than controls

cardiovascular system
decreased systemic arterial blood pressure ( J:88337 )
• while blood pressure is normal in conscious mutants, it is reduced relative to that of wild-type controls in mutants under anesthesia
• associated with increases in basal levels of S-nitrosothiol (SNO)

homeostasis/metabolism
abnormal metabolism ( J:88337 )
• in induced endotoxic shock, metabolism of endogenously generated nitrosothiols is severely impaired
increased physiological sensitivity to xenobiotic ( J:88337 )
• reduced blood pressure relative to wild-type controls after administration of urethane anesthetic

immune system
increased susceptibility to bacterial infection ( J:88337 )
• increased S-nitrosylation, tissue damage, and mortality following LPS-challenge and induced sepsis
increased susceptibility to bacterial infection induced morbidity/mortality ( J:88337 )
• 48% mortality from LPS-induced shock compared to 15% of wild-type mice
• higher mortality from bacterial septic shock than controls




Genotype
MGI:5049929
hm2
Allelic
Composition		 Adh5tm1Stam/Adh5tm1Stam
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1Stam mutation (1 available); any Adh5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173666 )
• diethylnitrosamine (DEN)-challenged mice exhibit decreased survival compared with similarly treated wild-type mice

mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173666 )
• diethylnitrosamine (DEN)-challenged mice exhibit decreased survival compared with similarly treated wild-type mice




Genotype
MGI:5049930
cx3
Allelic
Composition		 Adh5tm1Stam/Adh5tm1Stam
Nos2tm1Lau/Nos2tm1Lau
Genetic
Background		 involves: 129 * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1Stam mutation (1 available); any Adh5 mutation (27 available)
Nos2tm1Lau mutation (8 available); any Nos2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:173666 )
N
• mice exhibit normal survival following diethylnitrosamine (DEN) challenged




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory