Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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neoplasm
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• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment
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nervous system
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• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm1Tyj mutation
(5 available);
any
Rb1 mutation
(106 available)
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
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neoplasm
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• mice develop gliomas in the same pattern and with the same pathology as in Tg(S100b-v-erbB)4496Waw mice
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nervous system
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• mice develop gliomas in the same pattern and with the same pathology as in Tg(S100b-v-erbB)4496Waw mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
Trp53tm1Brd mutation
(5 available);
any
Trp53 mutation
(232 available)
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mortality/aging
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• 80% of mice die within 6 months of high grade oligodendroglioma
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neoplasm
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• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
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• 80% of mice die within 6 months of high grade oligodendroglioma
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nervous system
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• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Trp53 allele
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• 80% of mice die within 6 months of high grade oligodendroglioma
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
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mortality/aging
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• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma
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neoplasm
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• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
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• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma
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• mice exhibit decreased latency of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
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nervous system
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• mice exhibit increased penetrance of glioma development compared to Tg(S100b-v-erbB)4496Waw mice
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• 75% of mice die by 2 months of age and 90% of mice are dead by 6 months due to development of oligodendroglioma
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
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|
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neoplasm
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• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Cdkn2a allele
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nervous system
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• mice develop gliomas as in Cdkn2atm1Rdp/Cdkn2atm1Rdp Tg(S100b-v-erbB)4496Waw mice with loss of function of the wild-type Cdkn2a allele
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation
(1 available)
|
|
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mortality/aging
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• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice (63%) die due to glioma development with the exception of 4 mice that die of unknown causes
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neoplasm
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• mice develop oligodendroglioma
• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice die due to glioma development with the exception of 4 mice that die of unknown causes
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nervous system
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• mice develop oligodendroglioma
• within 6 months, 50% of mice die or are euthanized due to glioma development
• after 1 year, 24 of 38 mice die due to glioma development with the exception of 4 mice that die of unknown causes
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