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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efnb2tm4Kln
targeted mutation 4, Rudiger Klein
MGI:3026687
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Efnb2tm4Kln/Efnb2tm4Kln
Tg(Camk2a-cre)159Kln/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3026783
cn2
 		Efnb2tm4Kln/Efnb2tm4Kln
Tg(Nes-cre)1Kln/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3026784


Genotype
MGI:3026783
cn1
Allelic
Composition		 Efnb2tm4Kln/Efnb2tm4Kln
Tg(Camk2a-cre)159Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm4Kln mutation (0 available); any Efnb2 mutation (28 available)
Tg(Camk2a-cre)159Kln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:87398 )
N
• mice showed no overt behavioral abnormalities

nervous system
nervous system phenotype ( J:87398 )
N
• normal hippocampal architecture
reduced long-term potentiation ( J:87398 )
• reduced early LTP but no significant defects of basal synaptic transmission parameters or NMDA receptor component




Genotype
MGI:3026784
cn2
Allelic
Composition		 Efnb2tm4Kln/Efnb2tm4Kln
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm4Kln mutation (0 available); any Efnb2 mutation (28 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:87398 )
N
• normal hippocampal architecture
abnormal long-term depression ( J:87398 )
• reduced long term depression




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory