Phenotypes associated with this allele

• Allele Symbol: Txnip^Hyplip1
• Allele Name: hyperlipidemia 1
• Allele ID: MGI:2687368
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Txnip^Hyplip1/Txnip^Hyplip1	B6.HcB19-Txnip^Hyplip1	MGI:3719425
hm2	Txnip^Hyplip1/Txnip^Hyplip1	HcB19/Dem-Txnip^Hyplip1	MGI:3719414
hm3	Txnip^Hyplip1/Txnip^Hyplip1	involves: CAST/Ei * HcB19/Dem	MGI:3719416
ht4	Txnip^Hyplip1/Txnip^+	involves: CAST/Ei * HcB19/Dem	MGI:3719415

Genotype
MGI:3719425

hm1

• Allelic Composition: Txnip^Hyplip1/Txnip^Hyplip1
• Genetic Background: B6.HcB19-Txnip^Hyplip1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:102224 )

• lipogenesis is increased relative to wild-type mice

increased fatty acids level ( J:102224 )

• nonesterified fatty acid levels are increased relative to wild-type mice

liver/biliary system

increased liver weight ( J:102224 )

growth/size/body

increased liver weight ( J:102224 )

Genotype
MGI:3719414

hm2

• Allelic Composition: Txnip^Hyplip1/Txnip^Hyplip1
• Genetic Background: HcB19/Dem-Txnip^Hyplip1

neoplasm

increased hepatocellular carcinoma incidence ( J:112292 )

• 41% of mice develop hepatocellular carcinomas tumors when control mice have no tumors

• some hepatic tumors observed form in more than one lobe

• tumor incidence increases with age starting at 8 months and reach 66% incidence by 20 to 24 months of age

• tumors are multifocal, some are red and black in color indicating hemorrhaging, some display fibrosis, some are yellow in color indicating the presence of fat deposits, contain macrovesicular fat, and form regeneration nodules

• males exhibit a higher incidence of tumors than females

• however, no preneoplastic increase in proliferation is observed

homeostasis/metabolism

increased circulating cholesterol level ( J:47109 )

• total cholesterol levels are elevated 30% to 60% relative to controls

increased circulating VLDL cholesterol level ( J:47109 )

• the number of VLDL particles is increased

increased circulating triglyceride level ( J:47109 )

• plasma triglyceride levels are 10- to 30-fold higher than in control mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:112292 )

• 41% of mice develop hepatocellular carcinomas tumors when control mice have no tumors

• some hepatic tumors observed form in more than one lobe

• tumor incidence increases with age starting at 8 months and reach 66% incidence by 20 to 24 months of age

• tumors are multifocal, some are red and black in color indicating hemorrhaging, some display fibrosis, some are yellow in color indicating the presence of fat deposits, contain macrovesicular fat, and form regeneration nodules

• males exhibit a higher incidence of tumors than females

• however, no preneoplastic increase in proliferation is observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:112292

Genotype
MGI:3719416

hm3

• Allelic Composition: Txnip^Hyplip1/Txnip^Hyplip1
• Genetic Background: involves: CAST/Ei * HcB19/Dem

neoplasm

increased hepatocellular carcinoma incidence ( J:112292 )

• 52 of 108 mice develop tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:112292 )

• 52 of 108 mice develop tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:112292

Genotype
MGI:3719415

ht4

• Allelic Composition: Txnip^Hyplip1/Txnip⁺
• Genetic Background: involves: CAST/Ei * HcB19/Dem

neoplasm

increased hepatocellular carcinoma incidence ( J:112292 )

• 4 of 72 mice develop tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:112292 )

• 4 of 72 mice develop tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:112292