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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Rho)1Wbae
transgene insertion 1, Wolfgang Baehr
MGI:2686794
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(CAG-EGFP)1Osb/0
Tg(Rho)1Wbae/0
involves: C57BL/6 * SJL MGI:4366757
tg2
Tg(Rho)1Wbae/0 involves: C57BL/6 * SJL MGI:2686810


Genotype
MGI:4366757
cx1
Allelic
Composition
Tg(CAG-EGFP)1Osb/0
Tg(Rho)1Wbae/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)1Osb mutation (8 available)
Tg(Rho)1Wbae mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice

vision/eye
• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice




Genotype
MGI:2686810
tg2
Allelic
Composition
Tg(Rho)1Wbae/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

vision/eye
• progressive reduction of both rod and cone photoreceptors with age
• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
• reduction in thickness of the outer nuclear layer
• ERGs from dark-adapted mutants show a significant reduction in teh amplitudes of a and b waves at P30
• between P30 and P210, the a wave gradually decreases and the b wave is reduced to about 30% of normal

nervous system
• progressive reduction of both rod and cone photoreceptors with age
• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
J:12791





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/14/2022
MGI 6.19
The Jackson Laboratory