Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-EGFP)1Osb mutation
(8 available)
Tg(Rho)1Wbae mutation
(0 available)
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nervous system
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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vision/eye
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• double mutants exhibit the same level of retinal degeneration as is observed in hemizygous Tg(Rho)1Wbae mice
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Allelic Composition |
Tg(Rho)1Wbae/0
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Genetic Background |
involves: C57BL/6 * SJL |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice
vision/eye
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• progressive reduction of both rod and cone photoreceptors with age
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• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
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• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
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• reduction in thickness of the outer nuclear layer
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• ERGs from dark-adapted mutants show a significant reduction in teh amplitudes of a and b waves at P30
• between P30 and P210, the a wave gradually decreases and the b wave is reduced to about 30% of normal
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nervous system
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• progressive reduction of both rod and cone photoreceptors with age
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• light-sensitive outer segments are about 50% of normal length by P20 and continue to shorten over time
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• slow degeneration that progresses over 50% of the lifetime of a normal mouse
• associated with a decrease in light-evoked electroretinogram response
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