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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
F13a1tm1Gdi
targeted mutation 1, Gerhard Dickneite
MGI:2684302
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
F13a1tm1Gdi/F13a1tm1Gdi involves: 129P2/OlaHsd MGI:2684307
hm2
F13a1tm1Gdi/F13a1tm1Gdi involves: 129P2/OlaHsd * CBA/Ca MGI:2684306
ht3
F13a1tm1Gdi/F13a1+ involves: 129P2/OlaHsd MGI:3714047


Genotype
MGI:2684307
hm1
Allelic
Composition
F13a1tm1Gdi/F13a1tm1Gdi
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F13a1tm1Gdi mutation (0 available); any F13a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Altered response to myocardial infraction in F13a1tm1Gdi/F13a1tm1Gdi mice

mortality/aging
• daily intravenous replenishment of F13a1 for 5 days restores survival (J:121502)
• all die within 5 days after myocardial infarction from left ventricular rupture (J:121502)
• all die within 5 days after myocardial infarction from left ventricular rupture (J:121502)
• daily intravenous replenishment of F13a1 for 5 days restores survival (J:121502)

cardiovascular system
• observed in some male mice (J:86919)
• observed in some male mice (J:86919)
• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)
• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)
• intrauterine bleeding (J:86919)
• intrauterine bleeding (J:86919)
• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)
• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)

reproductive system
• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)
• following myocardial infarction, intrathoracic hematoma is seen adjacent to the experimental anterolateral infarction (J:129358)
• intrauterine bleeding (J:86919)
• intrauterine bleeding (J:86919)
• intrauterine fetal death due to placental hemorrhage (J:86919)
• intrauterine fetal death due to placental hemorrhage (J:86919)

respiratory system
• observed in some male mice (J:86919)
• observed in some male mice (J:86919)

homeostasis/metabolism
• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)
• mutants subjected to coronary ligation die within 5 days and exhibit hemothorax, myocardial rupture of the left ventricular wall, and reduced inflammatory response in the infarct (J:121502)

Mouse Models of Human Disease
OMIM ID Ref(s)
Factor XIII, A Subunit, Deficiency of 613225 J:86919




Genotype
MGI:2684306
hm2
Allelic
Composition
F13a1tm1Gdi/F13a1tm1Gdi
Genetic
Background
involves: 129P2/OlaHsd * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F13a1tm1Gdi mutation (0 available); any F13a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• ~30% of homozygotes die within 12 months after birth (J:87293)
• in these mice, bleeding time is only modestly prolonged by a factor of 2, suggesting that impaired clot integrity and stability, rather than delayed clot formation, may contrubute to increased mortality (J:87293)
• ~30% of homozygotes die within 12 months after birth (J:87293)
• in these mice, bleeding time is only modestly prolonged by a factor of 2, suggesting that impaired clot integrity and stability, rather than delayed clot formation, may contrubute to increased mortality (J:87293)
• an increase in maternal lethality (~50%) is observed in female homozygotes during gestation (J:87293)
• an increase in maternal lethality (~50%) is observed in female homozygotes during gestation (J:87293)

cardiovascular system
• homozygotes display spontaneous fatal hemorrhage, including hemothorax, hemoperitoneum, and subcutaneous bleeding (J:87293)
• homozygotes display spontaneous fatal hemorrhage, including hemothorax, hemoperitoneum, and subcutaneous bleeding (J:87293)

homeostasis/metabolism
N
• homozygotes show no significant differences in the extent of platelet aggregation induced by thrombin, ADP, or collagen relative to wild-type control mice (J:87293)
• in vitro, the global coagulation properties of blood from homozygous mutant mice, including activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) are indistinguishable from those of control mice (J:87293)
• homozygotes show no significant differences in the extent of platelet aggregation induced by thrombin, ADP, or collagen relative to wild-type control mice (J:87293)
• in vitro, the global coagulation properties of blood from homozygous mutant mice, including activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) are indistinguishable from those of control mice (J:87293)
• in vitro, thrombelastography indicates impaired clot strength and rapid degradation of the mechanical properties of the clot in blood from mutant mice relative to 129 or CBA control mice (J:87293)
• however, replacement of mutant mice with human plasma F13A1 restores the mechanical properties of the clot to near normal values in a dose-dependent manner (J:87293)
• in vitro, thrombelastography indicates impaired clot strength and rapid degradation of the mechanical properties of the clot in blood from mutant mice relative to 129 or CBA control mice (J:87293)
• however, replacement of mutant mice with human plasma F13A1 restores the mechanical properties of the clot to near normal values in a dose-dependent manner (J:87293)
• mean tail-tip bleeding time is significantly increased in homozygous mutant mice relative to 129 or CBA control mice (J:87293)
• however, replacement of mutant mice with human plasma F13A1 (200 U/kg i.v.) increases plasma activity to normal levels of ~135% and restores tail-tip bleeding time to within normal range (J:87293)
• mean tail-tip bleeding time is significantly increased in homozygous mutant mice relative to 129 or CBA control mice (J:87293)
• however, replacement of mutant mice with human plasma F13A1 (200 U/kg i.v.) increases plasma activity to normal levels of ~135% and restores tail-tip bleeding time to within normal range (J:87293)

reproductive system
• female homozygotes are fertile; however, pregnancy is severely impaired (J:87293)
• female homozygotes are fertile; however, pregnancy is severely impaired (J:87293)

respiratory system

hematopoietic system
N
• homozygotes display no significant differences in platelet number, total white blood cell count, or erythrocyte number relative to wild-type mice (J:87293)
• homozygotes display no significant differences in platelet number, total white blood cell count, or erythrocyte number relative to wild-type mice (J:87293)

Mouse Models of Human Disease
OMIM ID Ref(s)
Factor XIII, A Subunit, Deficiency of 613225 J:87293




Genotype
MGI:3714047
ht3
Allelic
Composition
F13a1tm1Gdi/F13a1+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F13a1tm1Gdi mutation (0 available); any F13a1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all die within 5 days after myocardial infarction from left ventricular rupture (J:121502)
• all die within 5 days after myocardial infarction from left ventricular rupture (J:121502)

cardiovascular system
• mutants subjected to coronary ligation die within 5 days (J:121502)
• mutants subjected to coronary ligation die within 5 days (J:121502)

homeostasis/metabolism
• mutants subjected to coronary ligation die within 5 days (J:121502)
• mutants subjected to coronary ligation die within 5 days (J:121502)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory