F13a1tm1Gdi
Targeted Allele Detail
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Symbol: |
F13a1tm1Gdi |
Name: |
coagulation factor XIII, A1 subunit; targeted mutation 1, Gerhard Dickneite |
MGI ID: |
MGI:2684302 |
Synonyms: |
FXIII-, FXIII-A- |
Gene: |
F13a1 Location: Chr13:37051152-37234220 bp, - strand Genetic Position: Chr13, 14.44 cM
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Alliance: |
F13a1tm1Gdi page
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Altered response to myocardial infraction in F13a1tm1Gdi/F13a1tm1Gdi mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:87293
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 2.5 kb fragment encompassing exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. Both coagulation factor XIII enzymatic activity and fibrin gamma-dimerization were undetected in plasma from homozygous mutant mice.
(J:87293)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any F13a1 Mutation: |
47 strains or lines available
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Original: |
J:87293 Lauer P, et al., Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb Haemost. 2002 Dec;88(6):967-74 |
All: |
19 reference(s) |
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