Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
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cardiovascular system
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• following ischemia and reperfusion with SB216763 (a GSK3b inhibitor) and rapamycin treatment
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• following 2 hours of ischemia without reperfusion
• not affected by treatment with SB216763 (a GSK3b inhibitor) and rapamycin
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
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mortality/aging
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• embryonic lethality, time not specified
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Allelic
Composition |
Becn1tm1Blev/Becn1+
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Genetic
Background |
involves: 129X1/SvJ * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
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mortality/aging
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• mutants show some tumor-associated mortality at 6 to 8 months of age
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homeostasis/metabolism
neoplasm
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• 15% of mutants at 13-18 months of age exhibit palpable tumors compared to 1% of wild-type mice
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• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants
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• mutants have an increased frequency of lung lesions in earlier stages of neoplasia, including hyperplastic alveolar epithelium resembling human atypical adenomatous hyperplasia and bronchioalveolar adenomas composed of monomorphous cells with minimal cytologic atypia
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• develop lymphomas that occur more frequently, at an earlier age, are more likely to present as palpable masses than in wild-type, including diffuse large-cell lymphoma, follicular lymphoma, immunoblastic variant of diffuse large-cell lymphoma, anaplastic plasmacytoma, and histiocytic sarcoma
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• mutants have a higher probability of having a malignancy (30%) than wild-type (14%); malignancies do not contain mutations in the wild-type Becn1 allele
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• well-differentiated hepatocellular carcinomas
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• greater number of and larger lung carcinomas than in wild-type mice
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• lung cancers show features of well-differentiated human papillary adenocarcinomas
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• anaplastic plasmacytoma
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liver/biliary system
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• well-differentiated hepatocellular carcinomas
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respiratory system
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• mutants have an increased frequency of lung lesions in earlier stages of neoplasia, including hyperplastic alveolar epithelium resembling human atypical adenomatous hyperplasia and bronchioalveolar adenomas composed of monomorphous cells with minimal cytologic atypia
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• greater number of and larger lung carcinomas than in wild-type mice
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• lung cancers show features of well-differentiated human papillary adenocarcinomas
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cellular
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• germinal center B lymphocytes have fewer autophagic vacuoles than wild-type lymphocytes 10 days after immunization with sheep red blood cells, indicating reduced autophagic activity
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endocrine/exocrine glands
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• mammary ducts are frequently abnormal, with multiple layers of epithelial cells and intraluminal collections of epithelial cells
• hyperproliferation of mammary ductal epithelial cells in the terminal end buds
• mammary ducts show increase in DNA synthesis
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• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants
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hematopoietic system
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• mutants show an increase in the number of germinal centeres in the spleens following immunization with sheep red blood cells at 2 months of age
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• mutants show an increase in the size of germinal centers in the spleens following immunization with sheep red blood cells at 2 months of age
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immune system
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• increase in frequency of extranodal, splenic, and nodal lymphoproliferative disease
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• mutants show an increase in the number of germinal centeres in the spleens following immunization with sheep red blood cells at 2 months of age
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• mutants show an increase in the size of germinal centers in the spleens following immunization with sheep red blood cells at 2 months of age
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integument
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• mammary ducts are frequently abnormal, with multiple layers of epithelial cells and intraluminal collections of epithelial cells
• hyperproliferation of mammary ductal epithelial cells in the terminal end buds
• mammary ducts show increase in DNA synthesis
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• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
Tg(Alb1HBV)44Bri mutation
(1 available)
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neoplasm
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• mutants exhibit accelerated development of HBV-induced premalignant lesions compared to hemizygous Tg(Alb1HBV)44Bri mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation
(5 available)
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cellular
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• mutants show decreased autophagy during starvation conditions in muscle and bronchial epithelial cells
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation
(1 available);
any
Becn1 mutation
(35 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation
(5 available)
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cellular
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• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles
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homeostasis/metabolism
behavior/neurological
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• mice exhibit decreased maximal treadmill running distance compared with wild-type mice
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Analysis Tools