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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ets2tm2Rgo
targeted mutation 2, Robert G Oshima
MGI:2682649
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ets2tm2Rgo/Ets2tm2Rgo involves: FVB/N MGI:2682667
ht2
Ets2tm2Rgo/Ets2tm5.2Rgo involves: 129/Sv * C57BL/6 * FVB/N MGI:4353411
ht3
Ets2tm2Rgo/Ets2tm1Rgo involves: FVB/N MGI:2682668
cn4
Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:3769401
cx5
Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo
involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353402


Genotype
MGI:2682667
hm1
Allelic
Composition
Ets2tm2Rgo/Ets2tm2Rgo
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transplanted mammary tumors only developed to about half the size of controls
• growth of mammary tumors resulting from trasgenic polyoma virus or transgenic Neu were similarly restricted in growth
• homozygotes are viable, fertile, and live normal life spans




Genotype
MGI:4353411
ht2
Allelic
Composition
Ets2tm2Rgo/Ets2tm5.2Rgo
Genetic
Background
involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
Ets2tm5.2Rgo mutation (0 available); any Ets2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2682668
ht3
Allelic
Composition
Ets2tm2Rgo/Ets2tm1Rgo
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (28 available)
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo

cardiovascular system




Genotype
MGI:3769401
cn4
Allelic
Composition
Ets2tm2Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (28 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around mid-gestation




Genotype
MGI:4353402
cx5
Allelic
Composition
Ets1tm1Jml/Ets1tm1Jml
Ets2tm2Rgo/Ets2tm2Rgo
Genetic
Background
involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (15 available)
Ets2tm2Rgo mutation (0 available); any Ets2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected embryos are seen at E11.5 with all lost before E15.5
• fewer than expected embryos are seen at E11.5 with all lost before E15.5

cellular
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
• striking decrease in vascular complexity at E10.5
• defect in branching is also seen at E9.5 and E11.5
• increase in inter blood vessel spacing
• dilation is often seen at E10.5 with the distinction between large and small vessels unclear
• at E11.5, some embryos have large visibly dilated blood vessels
• seen at E11.5 in some embryos
• increase in endothelial cell apoptosis at E11.5 and E13.5

homeostasis/metabolism
• seen at E11.5 in some embryos

embryo
N
• in embryos without visible vascular abnormalities, no defects are detected in the placental labyrinth layer





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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory