Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation
(0 available);
any
Ets2 mutation
(37 available)
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neoplasm
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• transplanted mammary tumors only developed to about half the size of controls
• growth of mammary tumors resulting from trasgenic polyoma virus or transgenic Neu were similarly restricted in growth
• homozygotes are viable, fertile, and live normal life spans
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm2Rgo mutation
(0 available);
any
Ets2 mutation
(37 available)
Ets2tm5.2Rgo mutation
(0 available);
any
Ets2 mutation
(37 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation
(1 available);
any
Ets2 mutation
(37 available)
Ets2tm2Rgo mutation
(0 available);
any
Ets2 mutation
(37 available)
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mortality/aging
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• death occurs around E11.5
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embryo
cardiovascular system
mortality/aging
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• mice die around mid-gestation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation
(0 available);
any
Ets1 mutation
(25 available)
Ets2tm2Rgo mutation
(0 available);
any
Ets2 mutation
(37 available)
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mortality/aging
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• fewer than expected embryos are seen at E11.5 with all lost before E15.5
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• fewer than expected embryos are seen at E11.5 with all lost before E15.5
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cellular
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• increase in endothelial cell apoptosis at E11.5 and E13.5
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cardiovascular system
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• striking decrease in vascular complexity at E10.5
• defect in branching is also seen at E9.5 and E11.5
• increase in inter blood vessel spacing
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• dilation is often seen at E10.5 with the distinction between large and small vessels unclear
• at E11.5, some embryos have large visibly dilated blood vessels
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• seen at E11.5 in some embryos
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• increase in endothelial cell apoptosis at E11.5 and E13.5
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homeostasis/metabolism
embryo
N |
• in embryos without visible vascular abnormalities, no defects are detected in the placental labyrinth layer
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