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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igh-Jtm1(VDJ-VI10)Zbz
targeted mutation 1, Universitatsspital Zurich, Biologisches Zentrallaboratorium
MGI:2681437
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Igh-Jtm1(VDJ-VI10)Zbz/Igh-J+ involves: C57BL/6 * C57BL/6J * BALB/cJ MGI:2681465


Genotype
MGI:2681465
ht1
Allelic
Composition		 Igh-Jtm1(VDJ-VI10)Zbz/Igh-J+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1(VDJ-VI10)Zbz mutation (0 available); any Igh-J mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune serum protein physiology ( J:86411 )
• high levels of VSV neutralizing antibodies are found in preimmunized mice (containing equal amounts of IgM and IgG)
• mice mounted a significant and faster response to infection
• titers don't reach levels seen in wild-type mice
• augmentation of isotype switching does not occur before day 6




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory