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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ctf1tm1Msd
targeted mutation 1, Michael Sendtner
MGI:2675769
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ctf1tm1Msd/Ctf1tm1Msd B6.Cg-Ctf1tm1Msd MGI:5294956
hm2
Ctf1tm1Msd/Ctf1tm1Msd involves: C57BL/6 MGI:2675784


Genotype
MGI:5294956
hm1
Allelic
Composition
Ctf1tm1Msd/Ctf1tm1Msd
Genetic
Background
B6.Cg-Ctf1tm1Msd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctf1tm1Msd mutation (1 available); any Ctf1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mutants develop spontaneous adult-onset obesity, with weight gain first seen starting at 6 months of age
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice

adipose tissue
• weight gain is mostly due to increased adipose tissue
• adipocyte hypertrophy is seen in mature mutants

behavior/neurological
• mutants become obese despite reduced food intake from 2-12 months compared to controls

homeostasis/metabolism
• hyperglycemia is seen from 6 months of age
• hyperinsulinemia is seen from 6 months of age
• increase in serum leptin levels in parallel with progression of weight gain
• hypercholesterolemia is seen from 6 months of age
• old obese mutants exhibit lower circulating free fatty acids than controls
• in 2 month old mutants, energy expenditure is reduced compared to wild-type mice, with differences increasing with age
• 2 month old mutants fed a high-fat diet for 12 weeks gain more weight and accumulate more epididymal, retroperitoneal, and subcutaneous fat mass than wild-type mice
• in 2 month old mutants, oxygen consumption is reduced compared to wild-type mice, with differences increasing with age
• respiratory quotient is elevated in mature obese mutants compared to mature wild-type mice
• insulin resistance is seen in obese mutants
• adipocytes from obese mutants show increased baseline lipolysis and respond poorly to isoproterenol

endocrine/exocrine glands
• pancreatic islet number is increased at 9 and 12 months of age
• pancreatic islet size is increased at 9 and 12 months of age

cellular
• mitochondrial DNA levels are reduced in white adipose tissue, indicating impaired mitochondrial biogenesis
• oxygen consumption is reduced in adipocytes from obese mutants

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:176727




Genotype
MGI:2675784
hm2
Allelic
Composition
Ctf1tm1Msd/Ctf1tm1Msd
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctf1tm1Msd mutation (1 available); any Ctf1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the lumbar spinal cord, motoneuron loss is increased by 23% and 26% at P1 and P9, respectively
• in the thoracic spinal cord, motoneuron loss is increased by 29% and 43% at P1 and P9, respectively
• in the brachial spinal cord, motoneuron loss is increased by 30% and 40% at P1 and P9, respectively
• in the brainstem nuclei, facial motorneuron loss is increased by 24% and 22% at P1 and P9, respectively, by 20% at 4 weeks, and by 16% and 17% at 3 and 6 months, respectively, while hypoglossal motorneuron loss is increased by 23% at both P1 and P9
• however, no significant differences in motoneuron numbers are detected in the lumbar spinal cord at E13.5-E14.5 or in the facial nucleus at E15 relative to wild-type mice
• in addition, axotomized homozygotes show no significant further loss of motorneurons in the facial nucleus at 2 or 6 months relative to wild-type mice

behavior/neurological
• at 4 months of age, homozygotes display a significant reduction in grip strength relative to wild-type littermates
• however, loss of muscle strength does not result in any other obvious behavioral deficits





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory