Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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reproductive system
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• thin walls
• greatly reduced number of spermatogenic cells
• multinucleate giant cells in epithelium
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• abnormal meiotic figures observed in spermatocyte layers
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• 50% of males are sterile
• females are fully fertile
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endocrine/exocrine glands
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• thin walls
• greatly reduced number of spermatogenic cells
• multinucleate giant cells in epithelium
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cellular
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm3.1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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nervous system
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• hippocampal slices transfected with cre exhibit decreased dendritic spine numbers compared with control neurons
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm3.1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
N |
• mice exhibit normal proliferation rates throughout embryonic brain development, numbers of proliferating progenitor cells in the subventricular zone, and numbers of neural stem/progenitor cells
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• adult mice exhibit reduced spine length, width, and estimated spine volume compared with control mice
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• in the CA1 stratum radiatum, neurons exhibit reduced length of postsynaptic densities compared with control neurons
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• spontaneous excitatory postsynaptic current frequency in CA1 pyramidal neurons is reduced compared to in control neurons
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• field excitatory postsynaptic potential amplitude and slope are decreased compared to in control mice
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behavior/neurological
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• mice exhibit impaired performance in a Morris water maze and spatial reversal learning compared with control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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endocrine/exocrine glands
reproductive system
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• phenotype like that of homozygous Ccne2tm1Pisc but more severe
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• phenotype like that of homozygous Ccne2tm1Pisc but more severe
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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mortality/aging
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• expected number of homozygotes through E10.25
• only 50% of expected number of homozygotes found at E10.75
• no live double homozygotes after E11.5
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cardiovascular system
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• observed in embryos rescued by tetraploid complementation
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• abnormal patterning of the aortic arch, possibly resulting from a defect in neural crest migration
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• observed in embryos rescued by tetraploid complementation
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• observed in embryos rescued by tetraploid complementation
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embryo
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• normal morphogenesis and no pathological lesions despite growth retardation at E10.75
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• partial rescue of embryonic lethality by tetraploid complementation proves that a problem exists in the placenta
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• layer of trophoblast giant cells reduced or absent
• greatly reduced DNA content relative to expectation
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growth/size/body
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• normal morphogenesis and no pathological lesions despite growth retardation at E10.75
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hematopoietic system
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• observed in embryos rescued by tetraploid complementation
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• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation
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immune system
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• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm2.1Pisc mutation
(1 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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normal phenotype
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• mice are viable, fertile, and phenotypically normal
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