All Phenotypes Hmga1<tm1Cha> MGI Mouse

decreased male germ cell number ( J:84851 )

• a partial to total deficiency of male germ cells was observed within some chimeric seminiferous tubules

abnormal seminiferous tubule morphology ( J:84851 )

• sterile chimeric mice with >70% chimerism displayed more than 10% abnormal seminiferous tubules whereas a fertile chimera with 40% chimerism displayed less aberrant tubules

abnormal seminiferous tubule epithelium morphology ( J:84851 )

• chimeric mice with >70% chimerism displayed absence of normal seminiferous epithelia

abnormal Sertoli cell morphology ( J:84851 )

• Sertoli cells found within chimeric seminiferous tubules that lacked all germ cells appeared vacuolated

small seminiferous tubules ( J:84851 )

• chimeric seminiferous tubules with a 3% to 100% germ cell depletion displayed smaller than average tubule diameters

small testis ( J:84851 )

• at 5-8 months of age, chimeric testes were grossly reduced in size relative to wild-type testes

abnormal spermatogenesis ( J:84851 )

• no sperm carrying the disrupted allele were identified; all mature sperm obtained from heterozygous chimeras were derived from wild-type spermatocytes

• a sterile chimeric mouse with 90% chimerism showed complete absence of spermatocytes in >70% of aberrant seminiferous tubules, and only a few undifferentiated germ cells (spermatogonia) in the remaining (30%) tubules

azoospermia ( J:84851 )

• a sterile chimeric mouse with 90% chimerism showed complete absence of mature sperm in the epididymis, consistent with the finding that even the few germ cells found in the remaining (30%) aberrant regions of seminiferous tubules failed to develop to term

small epididymis ( J:84851 )

• at 5-8 months of age, chimeric epididymides were grossly reduced in size relative to wild-type epididymides

male infertility ( J:84851 )

• o none of the chimeric mice produced agouti (ES cell derived) progeny; 4 of 14 chimeras with a degree of chimerism greater than 70% were completely sterile