Mouse Genome Informatics
hm1
     Zfp423nur12/Zfp423nur12
involves: BALB/c * C57BL/6 * C3H
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype

Ataxia and malformation in Zfp423nur12/Zfp423nur12 mice

behavior/neurological

nervous system
abnormal choroid plexus morphology ( J:114758 )
• reduced choroids plexus of the 4th ventricle
abnormal hippocampus morphology ( J:114758 )
• reduced hippocampal formations
abnormal cerebellum morphology ( J:114758 )
• malformed
• pronounced anterior rotation of the cerebellum in the posterior fossa
• decreased cell proliferation in the germinal zones of the cerebellum
abnormal cerebellar cortex morphology ( J:114758 )
• Bergman glia fail to infiltrate the cerebellar cortex
• radial glial fibers found at lower densities than in controls
cerebellum vermis hypoplasia ( J:114758 )
• evident by E15.5

growth/size
decreased body weight ( J:114758 )
• P14 mutants show reduced weight gain

Mouse Models of Human Disease
 OMIM IDRef(s)
Dandy-Walker Syndrome; DWS 220200 J:114758


Mouse Genome Informatics
hm2
     Zfp423nur12/Zfp423nur12
Not Specified
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
complete lethality at weaning ( J:85113 )
• animals do not live long past weaning

behavior/neurological
tremors ( J:85113 )
• described as a quivering when moving


Mouse Genome Informatics
ht3
     Zfp423nur12/Zfp423Gt(XH542)Byg
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C3H
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological

nervous system
cerebellum hypoplasia ( J:114758 )
• mild cerebellar hypoplasia