Phenotypes associated with this allele

• Allele Symbol: Mt2^tm1Rch
• Allele Name: targeted mutation 1, Anna E Michalska
• Allele ID: MGI:2668455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mt1^tm1Rch/Mt1^tm1Rch Mt2^tm1Rch/Mt2^tm1Rch	involves: 129P2/OlaHsd * C57BL/6J	MGI:2675388

Genotype
MGI:2675388

cx1

• Allelic Composition: Mt1^tm1Rch/Mt1^tm1Rch; Mt2^tm1Rch/Mt2^tm1Rch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:120459 )

• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice

homeostasis/metabolism

increased circulating alanine transaminase level ( J:120459 )

• in acetaminophen-treated mice

abnormal ion homeostasis ( J:14416 )

• increased cadmium sensitivity

• take up a hunched back posture, ruffed coat and display general lethargy

abnormal lipid homeostasis ( J:120459 )

• acetaminophen-induced lipid peroxidation is increased compared to in similarly treated wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:120459 )

• mice are more sensitive to acetaminophen-induced lethality compared with similarly treated wild-type mice

increased physiological sensitivity to xenobiotic ( J:120459 )

• mice exhibit increased susceptibility to acetaminophen-induced hepatotoxicity, alanine aminotransferase, hepatic necrosis, lipid peroxidation, and lethality compared with similarly treated wild-type mice

• acetaminophen-induced injuries are not ameliorated by pretreatment with zinc unlike in similarly treated wild-type mice

• however, acetaminophen metabolism is normal

• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress compared with similarly treated wild-type cells

increased incidence of tumors by chemical induction ( J:120459 )

• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger

liver/biliary system

hepatic necrosis ( J:120459 )

• in acetaminophen-treated mice

abnormal hepatocyte morphology ( J:120459 )

• hepatocytes are more sensitive to acetaminophen and NAPQI-induced oxidative stress indicated by lactate dehydrogenase leakage compared with similarly treated wild-type cells

neoplasm

increased tumor incidence ( J:84369 )

• 90% of mice with tumors by 13 weeks (earliest tumors by 9 weeks)

increased incidence of tumors by chemical induction ( J:120459 )

• increased sensitivity to DMBA/TPA treatment; 100% of treated mice have tumors by 19 weeks, and only 10% of wild-type mice have tumors at 20 weeks, and the average tumor size of treated mice is 2X larger

cellular

hepatic necrosis ( J:120459 )

• in acetaminophen-treated mice