About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Wnt11tm1Amc
targeted mutation 1, Andrew P McMahon
MGI:2665014
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Wnt11tm1Amc/Wnt11tm1Amc involves: 129S1/Sv * 129X1/SvJ MGI:2665015
cx2
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
involves: 129 * C57BL/6 MGI:5444716
cx3
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1 MGI:2665016
cx4
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11tm1Amc
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1 MGI:2665019


Genotype
MGI:2665015
hm1
Allelic
Composition
Wnt11tm1Amc/Wnt11tm1Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt11tm1Amc mutation (2 available); any Wnt11 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants surviving to birth die within 2 days post-partum
• significant number of mutants die by E12.5

renal/urinary system
• kidneys of newborn mice have 64% the number of glomeruli found in wild-type
• kidney hypoplasia
• delayed kidney development resulting in abnormal ureteric branching morphogenesis
• at E12.5, there is loss of ureteric tips and some ampullae have abnormal morphology




Genotype
MGI:5444716
cx2
Allelic
Composition
Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (24 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (24 available)
Wnt11tm1Amc mutation (2 available); any Wnt11 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 100% of embryos (n=10) display cardiac defects
• most defects are VSDs

craniofacial
• in 11% of embryos (n=9)

digestive/alimentary system
• in 11% of embryos (n=9)

growth/size/body
• in 11% of embryos (n=9)




Genotype
MGI:2665016
cx3
Allelic
Composition
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Cos mutation (2 available); any Ret mutation (40 available)
Wnt11tm1Amc mutation (2 available); any Wnt11 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidneys are 52% the size of wild-type at E18.5




Genotype
MGI:2665019
cx4
Allelic
Composition
Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11tm1Amc
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Cos mutation (2 available); any Ret mutation (40 available)
Wnt11tm1Amc mutation (2 available); any Wnt11 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidneys are 44% the size of Wnt11-null kidneys and 67% the size of Ret,Wnt11 double heterozygotes
• ureteric branching is severely affected at E12.5, much mores so than in Wnt11 null embryos
• kidneys only have 2-4 ureteric buds at E12.5 compared to the normal 7 in wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory