All Phenotypes Tg(NES-TVA)J12Ech MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(NES-TVA)J12Ech
transgene insertion J12, Eric C Holland
MGI:2663944

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(NES-TVA)J12Ech/0 Trp53^tm1Brd/Trp53⁺	involves: 129 * C57BL/6 * FVB/N	MGI:3835348
cx2	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(NES-TVA)J12Ech/0	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:3835347
cx3	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:3835346
cx4	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(NES-TVA)J12Ech/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3835366
cx5	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0	involves: 129/Sv * C57BL/6 * FVB/N * SJL	MGI:3835361
cx6	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Tg(NES-TVA)J12Ech/0	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:3835358
tg7	Tg(NES-TVA)J12Ech/0	involves: 129 * C57BL/6 * FVB/N	MGI:3835345
tg8	Tg(NES-TVA)J12Ech/0	involves: FVB/N	MGI:3835357

Allelic Composition	Tg(NES-TVA)J12Ech/0 Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NES-TVA)J12Ech mutation (2 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased glioma incidence ( J:52161 )

• 3 of 8 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and Cdk4 develop gliomas compared to 1 of 8 similarly treated wild-type mice

• 17 of 39 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR, Cdk4, and bFGF develop gliomas compared to 3 of 29 similarly treated wild-type mice

• however, mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas

hydrocephaly ( J:52161 )

• in mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR, Cdk4, and bFGF

neoplasm

increased glioma incidence ( J:52161 )

• however, mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased glioma incidence ( J:52161 )

• 13 of 25 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

nervous system

increased glioma incidence ( J:52161 )

• 13 of 25 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased glioma incidence ( J:52161 )

• 8 of 19 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

• 4 of 10 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and Cdk4 develop gliomas compared to 1 of 8 similarly treated wild-type mice

• 6 of 16 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR, Cdk4, and bFGF develop gliomas compared to 3 of 29 similarly treated wild-type mice

hydrocephaly ( J:52161 )

• in mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and bFGF or Cdk4

neoplasm

increased glioma incidence ( J:52161 )

• 8 of 19 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (62 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 20% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 21 grade II (similar to human oligodendroglioma) and 1 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 21 grade II (similar to human oligodendroglioma) and 1 grade III (similar to anaplastic oligodendroglioma)

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 , J:153220 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 15% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice (J:125535)

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in improved survival compared to mice infected with RCAS-PDGFB alone (J:153220)

neoplasm

increased glioma incidence ( J:125535 )

• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)

increased oligodendroglioma incidence ( J:153220 )

• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice

• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation

• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

nervous system

increased glioma incidence ( J:125535 )

• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)

increased oligodendroglioma incidence ( J:153220 )

• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice

• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation

• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligodendroglioma		DOID:3181		J:153220

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 40% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 35 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 10 grade II (similar to human oligodendroglioma) and 12 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 35 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 10 grade II (similar to human oligodendroglioma) and 12 grade III (similar to anaplastic oligodendroglioma)

Allelic Composition	Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:52161 )

N	• mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR do not develop gliomas

Allelic Composition	Tg(NES-TVA)J12Ech/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 50% survival

neoplasm

increased glioma incidence ( J:125535 )

• 14 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 11 grade II (similar to human oligodendroglioma) and 3 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 14 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 11 grade II (similar to human oligodendroglioma) and 3 grade III (similar to anaplastic oligodendroglioma)

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