About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slit3tm1.1Dor
targeted mutation 1.1, David M Ornitz
MGI:2662358
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slit3tm1.1Dor/Slit3tm1.1Dor involves: 129S1/Sv * C57BL/6 MGI:5562646
hm2
Slit3tm1.1Dor/Slit3tm1.1Dor involves: 129S1/Sv * C57BL/6J MGI:2662361
cn3
Ndst1tm1Je/Ndst1tm1Je
Slit3tm1.1Dor/Slit3+
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5562648
cn4
Ndst1tm1Je/Ndst1tm1Je
Slit3tm1.1Dor/Slit3tm1.1Dor
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5562649
cx5
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor
involves: 129S1/Sv * 129S2/SvPas MGI:3043188
cx6
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3+
involves: 129S1/Sv * 129S2/SvPas MGI:3043191
cx7
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor
involves: 129S1/Sv * 129S2/SvPas MGI:5522767


Genotype
MGI:5562646
hm1
Allelic
Composition
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions
• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced
• vascular density and sprouting in diaphragmatic muscle is reduced

muscle
• vascular density and sprouting in diaphragmatic muscle is reduced
• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels
• tip endothelial cells are reduced by 89% in diaphragms
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions
• 86% of mice exhibit central tendon congenital diaphragmatic hernia

skeleton
• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital diaphragmatic hernia DOID:3827 OMIM:142340
OMIM:222400
OMIM:610187
J:208012




Genotype
MGI:2662361
hm2
Allelic
Composition
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• phenotype is stated to be identical to that of Slit3tm1Dor homozygotes; however, no data are presented in J:83292

growth/size/body

muscle

liver/biliary system

digestive/alimentary system

respiratory system

cardiovascular system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital diaphragmatic hernia DOID:3827 OMIM:142340
OMIM:222400
OMIM:610187
J:83292




Genotype
MGI:5562648
cn3
Allelic
Composition
Ndst1tm1Je/Ndst1tm1Je
Slit3tm1.1Dor/Slit3+
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1Je mutation (1 available); any Ndst1 mutation (3 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
Tg(Tek-cre)1Ywa mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice develop central tendon congenital diaphragmatic hernia with the same penetrance as seen in single Ndst1 conditional homozygotes




Genotype
MGI:5562649
cn4
Allelic
Composition
Ndst1tm1Je/Ndst1tm1Je
Slit3tm1.1Dor/Slit3tm1.1Dor
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1Je mutation (1 available); any Ndst1 mutation (3 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
Tg(Tek-cre)1Ywa mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• 100% of mice develop central tendon congenital diaphragmatic hernia compared to 57% of conditional Ndst1 homozygotes and 86% of Slit3 homozygotes




Genotype
MGI:3043188
cx5
Allelic
Composition
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (45 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (1 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)
• the lateral funiculus (white matter tract) is significantly thinner in triple homozygous mutants compared to controls

cellular
• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology
• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1tm1.1Matl homozygotes)




Genotype
MGI:3043191
cx6
Allelic
Composition
Slit1tm1.1Matl/Slit1tm1.1Matl
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3+
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1tm1.1Matl mutation (0 available); any Slit1 mutation (45 available)
Slit2tm1Matl mutation (2 available); any Slit2 mutation (1 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls
• the ventral commissure (bundle of nerve fibers passing from one side to the other in the spinal cord) appears thicker compared to controls
• the ventral funiculus (white matter tract) appears reduced in mutants compared to controls

cellular
• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls




Genotype
MGI:5522767
cx7
Allelic
Composition
Slit2tm1Matl/Slit2tm1Matl
Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit2tm1Matl mutation (2 available); any Slit2 mutation (1 available)
Slit3tm1.1Dor mutation (1 available); any Slit3 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in mammary gland ducts formed by transplanted mammary anlage

endocrine/exocrine glands
• in mammary gland ducts formed by transplanted mammary anlage
• mammary gland ducts formed by transplanted mammary anlage display hyperplasticity and organization defects, including mild to severe defects in ductal lumens and disrupted growth control, 100% penetrant phenotype

integument
• in mammary gland ducts formed by transplanted mammary anlage
• mammary gland ducts formed by transplanted mammary anlage display hyperplasticity and organization defects, including mild to severe defects in ductal lumens and disrupted growth control, 100% penetrant phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory