Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4mdig mutation
(1 available);
any
Lrp4 mutation
(97 available)
|
|
|
Lrp4mdig/Lrp4mdig with control
limbs/digits/tail
|
• digits are malformed on all 4 feet, some exhibiting brachydactyly, some syndactyly
|
|
• digits are malformed on all 4 feet, some exhibiting brachydactyly, some syndactyly
|
Allelic Composition |
Lrp4mdig/Lrp4mdig
|
|
Genetic Background |
involves: 129S2/SvPas * DBA/1LacJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4mdig mutation
(1 available);
any
Lrp4 mutation
(97 available)
|
|
|
limbs/digits/tail
|
• variable brachydactyly seen on all four limbs
|
|
• duplication of digits along the dorsoventral axis
|
|
• variable syndactyly seen on all four limbs
• typically involves fusion of 2 or 3 adjacent segments along the anteroposterior axis
|
behavior/neurological
|
• females and males are fertile but females sometimes fail to nurse their pups
|
craniofacial
N |
• no tooth abnormalities are seen
|
integument
|
• nails are often abnormally shaped or placed but are never fused
|