Mouse Genome Informatics
hm1
    Dync1h1Cra1/Dync1h1Cra1
C3HeB/FeJ-Dync1h1Cra1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die within 24 hours of birth

nervous system
• at E18.5, surviving neurons have inclusion bodies
• at E18.5, mice have lost 80% of anterior horn cells
• apoptosis levels in the anterior horn cells is increased

behavior/neurological
• at birth mice cannot feed
• at birth mice cannot move


Mouse Genome Informatics
ht2
    Dync1h1Cra1/Dync1h1+
C3HeB/FeJ-Dync1h1Cra1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• alpha motor neurons in the spinal cord anterior horn are decreased in number at 16 and 19 months

behavior/neurological
• latency to fall in a hanging testis reduced at 16 months of age (J:83128)
• mice show a reduced rotarod performance and reached latency to fall after 18 seconds on day 200 (J:107901)
• hindlimb and forelimb grip strength is reduced and 3 months and worsens at 16 months

muscle
• mice exhibit cramping when hung by their tails in which the whole body would start to tremble, then the forelimbs cramped, the neck stretched, the mouth opened and the tongue stuck out


Mouse Genome Informatics
ht3
    Dync1h1Cra1/Dync1h1+
involves: C3HeB/FeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
• Background Sensitivity: authors state that the phenotype observed is changed and milder than in Dync1h1Cra1 homozygotes


Mouse Genome Informatics
cx4
    Dync1h1Cra1/Dync1h1+
Tg(SOD1*G93A)1Gur/?

involves: C3HeB/FeJ * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice reach end stage by day 167 +/-2.5 SEM (standard error of measurement)

nervous system
• astrocytosis is evident in the cervical and lumbar spinal cord
• degeneration of the motor neurons in the cervical and lumbar spinal cord at end stage with astrocytosis and vacuolization
• degeneration of the motor neurons in the cervical and lumbar spinal cord is visible at end stage
• degeneration of the motor neurons in the cervical and lumbar spinal cord is visible at end stage

behavior/neurological
• motor activity is less than in Tg(SOD1*G93A)1Gur mice but does not deteriorate as quickly

growth/size
• weight reduction was not as severe as in Tg(SOD1*G93A)1Gur mice