Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
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immune system
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• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
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• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
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• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes
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• total leukocyte numbers, polymophonuclear cell numbers and mononuclear cell numbers are increased
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• 4-fold increase in the number of circulating neutrophils
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• NK cell cytotoxicity was reduced
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hematopoietic system
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• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
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• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
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• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes
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• total leukocyte numbers, polymophonuclear cell numbers and mononuclear cell numbers are increased
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• 4-fold increase in the number of circulating neutrophils
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• NK cell cytotoxicity was reduced
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cellular
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• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
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• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
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• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
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immune system
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit 20% less hemorrhage and 12% less accumulation of neutrophils compared to the thrombohemorrhagic vasculitis observed in wild type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
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immune system
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles
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cellular
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
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hematopoietic system
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
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immune system
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• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
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• neutrophil extravasation in response to TNF-alpha is dramatically decreased
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• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress
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• leukocytosis but do not develop spontaneous infections
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hematopoietic system
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• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
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• neutrophil extravasation in response to TNF-alpha is dramatically decreased
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• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress
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• leukocytosis but do not develop spontaneous infections
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cellular
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• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
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• neutrophil extravasation in response to TNF-alpha is dramatically decreased
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• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress
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Allelic
Composition |
Itgaltm1Bll/Itgal+
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Genetic
Background |
involves: 129S7/SvEvBrd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
|
|
|
immune system
|
|
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles
|
hematopoietic system
|
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• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3tm1Tq mutation
(0 available);
any
Edil3 mutation
(42 available)
Itgaltm1Bll mutation
(2 available);
any
Itgal mutation
(74 available)
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immune system
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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cellular
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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hematopoietic system
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
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Analysis Tools