All Phenotypes Gusb<tm4Sly> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gusb^tm4Sly
targeted mutation 4, William S Sly
MGI:2661042

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gusb^tm4Sly/Gusb^tm4Sly	involves: 129X1/SvJ * C57BL/6	MGI:2661058

Allelic Composition	Gusb^tm4Sly/Gusb^tm4Sly
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gusb^tm4Sly mutation (0 available); any Gusb mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• incomplete penetrance

craniofacial

abnormal neurocranium morphology ( J:83169 )

• sclerosis of the calvarium

shortened head ( J:83169 )

• progressive with age

growth/size/body

shortened head ( J:83169 )

• progressive with age

decreased body size ( J:83169 )

postnatal growth retardation ( J:83169 )

• progressive with age

hearing/vestibular/ear

deafness ( J:83169 )

limbs/digits/tail

short limbs ( J:83169 )

• progressive with age

skeleton

abnormal axial skeleton morphology ( J:83169 )

• dysplasia

abnormal neurocranium morphology ( J:83169 )

• sclerosis of the calvarium

osteosclerosis ( J:83169 )

• sclerotic long bones

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sly syndrome		DOID:12803	OMIM:253220	J:83169

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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