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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpc2tm1Dlc
targeted mutation 1, Catherine Dulac
MGI:2657154
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpc2tm1Dlc/Trpc2tm1Dlc involves: 129S1/Sv MGI:5461714
hm2
 		Trpc2tm1Dlc/Trpc2tm1Dlc involves: 129S1/Sv * C57BL/6 MGI:2657155
cx3
 		Trpc2tm1Dlc/Trpc2tm1Dlc
Trpc3tm1.1Bmil/Trpc3tm1.1Bmil 		involves: 129S1/Sv * FVB/N MGI:5461713


Genotype
MGI:5461714
hm1
Allelic
Composition		 Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythroblast morphology ( J:189490 )
• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells
abnormal erythrocyte physiology ( J:189490 )
• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells




Genotype
MGI:2657155
hm2
Allelic
Composition		 Trpc2tm1Dlc/Trpc2tm1Dlc
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
submission towards male mice ( J:74988 )
• absence of pheromone-induced aggression towards intruding males
abnormal mating preference ( J:74988 )
• males show indiscriminate mating behavior, mounting both male and female animals

nervous system
abnormal vomeronasal organ morphology ( J:74988 )
• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons
abnormal accessory olfactory bulb morphology ( J:74988 )
• loss of sensory afferents to the accessory olfactory bulb at 1 month of age
abnormal sensory neuron innervation pattern ( J:74988 )
• progressive loss of axon projections in the vomeronasal organ
abnormal nervous system electrophysiology ( J:74988 )
• vomeronasal sensory neurons do not not respond to urine phermones; waveform recorded in vomeronasal organ shows spontaneous firing but not stimulus-driven change in rate

respiratory system
abnormal vomeronasal organ morphology ( J:74988 )
• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

craniofacial
abnormal vomeronasal organ morphology ( J:74988 )
• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

growth/size/body
abnormal vomeronasal organ morphology ( J:74988 )
• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons




Genotype
MGI:5461713
cx3
Allelic
Composition		 Trpc2tm1Dlc/Trpc2tm1Dlc
Trpc3tm1.1Bmil/Trpc3tm1.1Bmil
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)
Trpc3tm1.1Bmil mutation (0 available); any Trpc3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythroblast morphology ( J:189490 )
• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells
abnormal erythrocyte physiology ( J:189490 )
• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory