Phenotypes associated with this allele

• Allele Symbol: Drd2^tm1Yyw
• Allele Name: targeted mutation 1, Yanyan Wang
• Allele ID: MGI:2656648
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd2^tm1Yyw/Drd2^tm1Yyw	B6.129S4-Drd2^tm1Yyw	MGI:3576286
hm2	Drd2^tm1Yyw/Drd2^tm1Yyw	involves: 129S4/SvJae * C57BL/6	MGI:3576285
hm3	Drd2^tm1Yyw/Drd2^tm1Yyw	involves: 129S4/SvJae * C57BL/6J	MGI:4441312
ht4	Drd2^tm1Yyw/Drd2^+	B6.129S4-Drd2^tm1Yyw	MGI:3576287

Genotype
MGI:3576286

hm1

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: B6.129S4-Drd2^tm1Yyw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:65770 , J:82829 )

• decreased haloperidol-induced catalepsy and inhibition of locomotion and rearing are seen compared to wild-type littermates (J:65770)

• D-amphetamine induced a different pattern of stereotypic behaviors in mutant mice compared to wild-type littermates (J:82829)

• apomorphine (a dopamine agonist) induced increased biting behavior but reduced climbing compared to wild-type mice (J:82829)

• co-administration of DRD1 and DRD2 agonists induces significantly more biting and less climbing behaviors compared to wild-type littermates (J:82829)

decreased anxiety-related response ( J:65770 )

• in an elevated zero-maze mutants spend less time in stretched attend postures

decreased vertical activity ( J:65770 )

decreased locomotor activity ( J:65770 )

• activity is reduced in an open field test and during both the diurnal and nocturnal periods when mutants were monitored in their home cages; however, circadian rhythms are normal

• fertility, body weight, coat color, and neuroanatomy are all normal

Genotype
MGI:3576285

hm2

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: involves: 129S4/SvJae * C57BL/6

behavior/neurological

impaired behavioral response to xenobiotic ( J:65770 )

• decreased haloperidol-induced catalepsy is seen compared to wild-type littermates

decreased anxiety-related response ( J:65770 )

• in an elevated zero-maze mutants spend less time in stretched attend postures

decreased vertical activity ( J:65770 )

decreased locomotor activity ( J:65770 )

• activity is reduced in an open field test

• fertility, body weight, coat color, and neuroanatomy are all normal

bradykinesia ( J:65770 )

• prolonged immobility is seen in the ring test compared to wild-type littermates

• this phenotype is only significant in the mixed background and not in mutants backcrossed to C57BL/6 for 5 generations

Genotype
MGI:4441312

hm3

• Allelic Composition: Drd2^tm1Yyw/Drd2^tm1Yyw
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

behavior/neurological

decreased aggression towards male mice ( J:103562 )

• unlike wild-type controls, resident male homozygotes display significantly reduced or absent offensive aggression towards wild-type A/J male intruders in the resident-intruder test

• at 6-7 months of age, most male homozygotes not only display a significantly reduced attack frequency and duration but show distinctly non-aggressive behaviors e.g. social grooming and peacefully keeping a short distance from the male intruder

• whereas old (15-18 months of age) and middle-aged (6-7 months of age) male homozygotes display a similar degree of offensive aggression, they both show significantly less aggression than young (2.5-4 months of age) male homozygotes

• young and middle-aged male homozygotes display significantly reduced offensive aggression relative to age-matched wild-type controls; however, no difference in aggression is observed between old homozygous mutant and wild-type males

• although an age-related reduction in offensive aggression is noted in both wild-type and mutant males, no significant differences in locomotor activity are observed between any two different age groups within the same genotype

Genotype
MGI:3576287

ht4

• Allelic Composition: Drd2^tm1Yyw/Drd2⁺
• Genetic Background: B6.129S4-Drd2^tm1Yyw

behavior/neurological

abnormal behavioral response to xenobiotic ( J:82829 )

• D-amphetamine induced a different pattern of stereotypic behaviors in heterozygotes mice compared to wild-type and homozygous mutant littermates