Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Imku mutation
(0 available);
any
Igbp1 mutation
(8 available)
Tg(Igbp1b-cre)1Imku mutation
(0 available)
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behavior/neurological
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• prolonged response latency compared to control mice
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• in probe trials using a Morris water maze, mutant mice spend less time in the quadrant where the hidden platform had been located
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nervous system
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N |
• brain morphology is similar to control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Igbp1tm1Imku mutation
(0 available);
any
Igbp1 mutation
(8 available)
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immune system
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• no somatic hypermutation takes place
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• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
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• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
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• reduced in numbers although normal numbers of pro B cells are present in bone marrow
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• germinal center formation is impaired
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• impaired proliferative responses, failure of G1/S transition
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• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production
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hematopoietic system
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• no somatic hypermutation takes place
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• decreased B220+ cells but cells have a normal maturation phenotype
• decreased numbers involve IgM+ IgDhi
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• CD23+IgM+ follicular cells in the spleen were reduced as were CD40+ cells
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• reduced in numbers although normal numbers of pro B cells are present in bone marrow
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• germinal center formation is impaired
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• impaired proliferative responses, failure of G1/S transition
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• stimulated antibody production is low
• T cell dependent antibody production more affected than T cell independent production
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cellular
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• impaired proliferative responses, failure of G1/S transition
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Imku mutation
(0 available);
any
Igbp1 mutation
(8 available)
Tg(Lck-cre)I57Jxm mutation
(1 available)
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immune system
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• largely lacking in double positive cells
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• demarcation between cortex and medulla indistinct
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• peripheral spleen T cells 30% of control levels
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• thymocyte production only 4.3% normal
• few proliferating thymocytes
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• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage
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hematopoietic system
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• largely lacking in double positive cells
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• demarcation between cortex and medulla indistinct
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• peripheral spleen T cells 30% of control levels
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• thymocyte production only 4.3% normal
• few proliferating thymocytes
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• double negative cells are proportionately higher but absolute numbers are reduced
• development blocked at DN3 stage
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endocrine/exocrine glands
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• largely lacking in double positive cells
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• demarcation between cortex and medulla indistinct
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• thymocyte production only 4.3% normal
• few proliferating thymocytes
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Analysis Tools