All Phenotypes Cd4<tm1Nik> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^tm1Nik
targeted mutation 1, Nigel Kileen
MGI:2654930

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655528
cn2	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655529
cn3	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2	MGI:2655530
cn4	Cd4^tm1Nik/Cd4^tm1Nik Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺	involves: 129X1/SvJ	MGI:4359002

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3778Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Litt mutation (4 available); any Cd4 mutation (82 available)
Cd4^tm1Nik mutation (2 available); any Cd4 mutation (82 available)
Tg(Lck-cre)3778Nik mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

abnormal interleukin-4 secretion ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal T-helper 2 physiology ( J:73479 )

• TH2-mediated IL-4 secretion is impaired but TH1 responses are normal

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

• however, T cells are capable of proliferating in vivo in response to antigenic stimulation

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-icre)3779Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

hematopoietic system

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

cellular

decreased T cell proliferation ( J:73479 )

• CD4+ T cells exhibit a smaller homeostatic proliferation response than in controls

Allelic Composition	Cd4^tm1Litt/Cd4^tm1Nik Tg(Lck-cre)3785Nik/0
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

decreased CD4-positive, alpha-beta T cell number ( J:73479 )

• few peripheral CD4 lineage T cells

increased CD8-positive, alpha-beta T cell number ( J:73479 )

• increase in CD8+ T cells in lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

hematopoietic system

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

decreased CD4-positive, alpha-beta T cell number ( J:73479 )

• few peripheral CD4 lineage T cells

increased CD8-positive, alpha-beta T cell number ( J:73479 )

• increase in CD8+ T cells in lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:73479 )

• CD4 lineage T cells exhibit an increase in proliferation and apoptosis

cellular

increased T cell apoptosis ( J:73479 )

• increase in apoptosis of CD4 lineage T cells

increased T cell proliferation ( J:73479 )

• increase in proliferation of peripheral CD4 lineage cells

Allelic Composition	Cd4^tm1Nik/Cd4^tm1Nik Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Nik mutation (2 available); any Cd4 mutation (82 available)
Tnfrsf4^tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal regulatory T cell physiology ( J:152472 )

• while the number of regulatory T cells is normal, they lack CD4 expression

• however, regulatory T cells are capable of suppressing T cell activity in vitro

hematopoietic system

abnormal regulatory T cell physiology ( J:152472 )

• while the number of regulatory T cells is normal, they lack CD4 expression

• however, regulatory T cells are capable of suppressing T cell activity in vitro

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