All Phenotypes Thra<tm2Ven> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm2Ven/Thra^tm2Ven	involves: 129P2/OlaHsd * BALB/c	MGI:2654873
hm2	Thra^tm2Ven/Thra^tm2Ven	involves: 129P2/OlaHsd * BALB/c * C57BL/6J	MGI:3700652
ht3	Thra^tm2Ven/Thra⁺	involves: 129P2/OlaHsd * BALB/c	MGI:3701137
ht4	Thra^tm2Ven/Thra^tm3Ven	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:3606072
cx5	Thra^tm2Ven/Thra^tm2Ven Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * BALB/c * C57BL/6J	MGI:3700828
cx6	Thra^tm2Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df	involves: 129P2/OlaHsd * BALB/c * C57BL/6J	MGI:3700829

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:72959 )

• at birth, the % of surviving pups obtained from heterozygous intercrosses may not display a Mendelian distribution, depending on environmental factors

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:72959 )

• adult homozygotes show a general disorganization of the thyroid follicles and flattening of the epithelium, as shown by uneven follicle sizes and reduced interstitial spaces

• however, no goiter is detected up to >18 months of age

abnormal thyroid gland physiology ( J:72959 )

• in response to TSH injections, homozygotes display reduced increases of free T3 and T4 serum levels relative to wild-type mice

• notably, homozygotes exhibit a mixed hyper- and hypothyroid phenotype, dependent on the tissue studied

decreased activity of thyroid gland ( J:72959 )

• homozygotes show signs of hypothyroidism, including significantly reduced levels of free T3 T4, poor responses to TSH, increased fat content, and skeletal defects associated with a late-onset growth retardation

increased activity of thyroid gland ( J:72959 )

• in addition to hypothyroidism, homozygotes display features of hyperthyroidism, including reduced body weight, elevated heart rate, and increased body temperature

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:72959 )

• homozygotes display significantly reduced serum levels of IGF-I relative to wild-type mice

decreased circulating thyroxine level ( J:72959 )

• both male and female homozygotes show significantly reduced free T4 levels in serum relative to wild-type littermates

decreased circulating triiodothyronine level ( J:72959 )

• both male and female homozygotes show significantly reduced free T3 levels in serum relative to wild-type littermates

• total T3 levels are significantly reduced only in female homozygotes

increased body temperature ( J:72959 )

• homozygotes display an increased body temperature (36.9 0.1 C) relative to wild-type mice (36.5 0.1 C)

abnormal thyroid-stimulating hormone level ( J:72959 )

• at 6-20 weeks, both male and female homozygotes display inappropriately normal serum levels of TSH, suggesting an alteration in the pituitary-thyroid axis

growth/size/body

decreased body weight ( J:72959 )

• both female and male homozygotes show a slightly reduced body weight from birth to adulthood relative to wild-type mice

obese ( J:72959 )

• adult homozygotes are obese

postnatal growth retardation ( J:72959 )

• both female and male homozygotes show a slightly delayed growth spurt during the first 9 weeks of life relative to wild-type mice

skeleton

abnormal osteoclast physiology ( J:72959 )

• homozygotes display a 57% reduction in osteoclast activity relative to wild-type mice

• in contrast, serum levels of osteocalcin, a marker of bone formation, remain unaffected

decreased bone mineral content ( J:72959 )

• homozygotes show a significant reduction in areal bone mineral (BM) content of the femur and L6 vertebrae relative to wild-type mice

decreased areal bone mineral density ( J:72959 )

• homozygotes show a significant reduction in areal bone mineral (BM) density of the femur and L6 vertebrae relative to wild-type mice

• however, no delay in the mineralization of the epiphysis is observed

abnormal compact bone morphology ( J:72959 )

• homozygotes exhibit decreased tibial cortical bone mineral content relative to wild-type mice

• however, no significant reduction in longitudinal bone growth is observed, such that tibias and femurs are of normal length

decreased compact bone area ( J:72959 )

• homozygotes exhibit decreased tibial cortical bone periosteal and endosteal circumferences, and cortical area relative to wild-type mice

abnormal trabecular bone morphology ( J:72959 )

• homozygotes display decreased trabecular bone mineral density (BMD), as shown by a 24% reduction in proximal tibia

adipose tissue

increased total body fat amount ( J:72959 )

• homozygotes exhibit a significant increase in fat content (121%) relative to wild-type mice

• however, serum levels of corticosterone and leptin are not significantly altered

reproductive system

prolonged estrous cycle ( J:72959 )

• female homozygotes display a slightly prolonged estrous cycle, suggesting aberrant ovulation

reduced female fertility ( J:72959 )

• female homozygotes generally fail to conceive

• female homozygotes display partial fertility but only under optimized animal care conditions

• homozygous intercrosses rarely generate litters

• Background Sensitivity: breeding abnormalities are exacerbated after the mutation is backcrossed for two generations onto the C57BL/6J background

behavior/neurological

abnormal pup retrieval ( J:72959 )

• if pups are born, female homozygotes fail to rear their offspring

cardiovascular system

increased heart rate ( J:72959 )

• homozygotes display a 10% increase in basal heart rate relative to wild-type littemates, despite their lower serum T3 levels

immune system

abnormal osteoclast physiology ( J:72959 )

• homozygotes display a 57% reduction in osteoclast activity relative to wild-type mice

• in contrast, serum levels of osteocalcin, a marker of bone formation, remain unaffected

hematopoietic system

abnormal osteoclast physiology ( J:72959 )

• homozygotes display a 57% reduction in osteoclast activity relative to wild-type mice

• in contrast, serum levels of osteocalcin, a marker of bone formation, remain unaffected

Allelic Composition	Thra^tm2Ven/Thra^tm2Ven
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm2Ven mutation (1 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:118402 )

N	• adult homozygotes display normal ABR thresholds in response to click and pure-tone (8, 16 and 32 kHz) stimuli, with typical waveforms of four to five peaks in the normal range (40-45 dB SPL)

Allelic Composition	Thra^tm2Ven/Thra⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm2Ven mutation (1 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thyroid gland physiology ( J:72959 )

• similar to homozygotes, heterozygotes exhibit a mixed hyper- and hypothyroid phenotype, dependent on the tissue studied

decreased activity of thyroid gland ( J:72959 )

• heterozygotes show signs of hypothyroidism, including significantly reduced levels of free T3 T4, increased fat content, and skeletal defects associated with a late-onset growth retardation

increased activity of thyroid gland ( J:72959 )

• in addition to hypothyroidism, heterozygotes display features of hyperthyroidism, including reduced body weight, elevated heart rate, and increased body temperature

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:72959 )

• heterozygotes display significantly reduced serum IGF-I levels, that are intermediate between those of wild-type and homozygous mutant mice

decreased circulating thyroxine level ( J:72959 )

• both male and female heterozygotes show significantly reduced free T4 levels in serum, that are intermediate between those of wild-type and homozygous mutant mice

decreased circulating triiodothyronine level ( J:72959 )

• both male and female heterozygotes show significantly reduced free T3 levels in serum, that are intermediate between those of wild-type and homozygous mutant mice

• total T3 levels are significantly reduced only in female heterozygotes

increased body temperature ( J:72959 )

• heterozygotes display an increased body temperature (36.7 0.1 C) relative to wild-type mice (36.5 0.1 C)

abnormal thyroid-stimulating hormone level ( J:72959 )

• at 6-20 weeks, both male and female heterozygotes display inappropriately normal serum levels of TSH, suggesting an alteration in the pituitary-thyroid axis

growth/size/body

decreased body weight ( J:72959 )

• both female and male heterozygotes show a slightly reduced body weight from birth to adulthood relative to wild-type mice

obese ( J:72959 )

• adult heterozygotes are obese

postnatal growth retardation ( J:72959 )

• both female and male heterozygotes show a slightly delayed growth spurt during the first 9 weeks of life relative to wild-type mice

skeleton

decreased bone mineral density ( J:72959 )

• heterozygotes display decreased trabecular bone mineral density (BMD), as shown by a 17% reduction in proximal tibia

abnormal compact bone morphology ( J:72959 )

• heterozygotes exhibit decreased tibial cortical bone mineral content relative to wild-type mice

decreased compact bone area ( J:72959 )

• heterozygotes exhibit decreased tibial cortical bone periosteal and endosteal circumferences, and cortical area relative to wild-type mice

abnormal trabecular bone morphology ( J:72959 )

• heterozygotes display decreased trabecular bone mineral density (BMD), as shown by a 17% reduction in proximal tibia

adipose tissue

increased total body fat amount ( J:72959 )

• similar to homozygotes, heterozygotes show a significant increase in fat content (121%) relative to wild-type mice

cardiovascular system

increased heart rate ( J:72959 )

• heterozygotes display a 10% increase in basal heart rate relative to wild-type littemates, despite their lower serum T3 levels

Allelic Composition	Thra^tm2Ven/Thra^tm3Ven
Genetic Background	involves: 129P2/OlaHsd * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm2Ven mutation (1 available); any Thra mutation (39 available)
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• compound heterozygous mutants exhibited 27% less body weight at 30 days of age compared with simple heterozygous Thra^tm2Ven/Thra⁺ controls

• 70-day-old compound heterozygous mice weighed only 5% less than simple heterozygous Thra^tm2Ven/Thra⁺ controls

Allelic Composition	Thra^tm2Ven/Thra^tm2Ven Thrb^tm1Df/Thrb^tm1Df
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm2Ven mutation (1 available); any Thra mutation (39 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:118402 )

• double homozygotes exhibit a retarded weight gain over the first 5 postnatal weeks, but only to the same extent as in single Thra^tm2Ven homozygotes

• no significant difference in postnatal weight gain is noted after 5 weeks

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:118402 )

• similar to Thra^tm2Ven mice, double homozygotes show thyroid follicles with a somewhat thin, flattened epithelium, but lack the enlargement observed in single Thrb^tm1Df homozygotes

homeostasis/metabolism

abnormal thyroid hormone level ( J:118402 )

• similar to Thra^tm2Ven mice, double homozygotes display normal TSH and slightly low T4 and T3 levels, indicating dominant suppression of the hormonal disorder observed in single Thrb^tm1Df homozygotes

decreased circulating thyroxine level ( J:118402 )

• similar to Thra^tm2Ven mice, double homozygotes display serum free T4 levels that are slightly but significantly below wild-type levels

decreased circulating triiodothyronine level ( J:118402 )

• similar to Thra^tm2Ven mice, double homozygotes display free T3 levels that are slightly but significantly below wild-type levels; total T3 is also slightly lowered

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:118402 )

• at 7-17 weeks of age, double homozygotes display normal ABR thresholds in response to click or pure-tone (8, 16, 32 kHz) stimuli, indicating suppression of the auditory defect observed in single Thrb^tm1Df homozygotes

• Background Sensitivity: on a mixed genetic background of equal parts 129/Sv, 129OlaHsd, BALB/c, and C57BL/6J strains, ABR responses are similar but more variable than those observed on a congenic C57BL/6J background

• consistent with rescued ABR thresholds, the developmental expression of the I_K,f potassium current in cochlear IHCs is also largely corrected at P30 relative to single Thrb^tm1Df homozygotes

Allelic Composition	Thra^tm2Ven/Thra⁺ Thrb^tm1Df/Thrb^tm1Df
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:118402 )

• mutant mice exhibit a less severely retarded weight gain over the first 4 postnatal weeks relative to Thra^tm2Ven homozygotes

• no significant difference in postnatal weight gain is noted by 5 weeks

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:118402 )

• at 7-17 weeks of age, mutant mice display normal ABR thresholds in response to click or pure-tone (8, 16, 32 kHz) stimuli, indicating suppression of the auditory defect observed in single Thrb^tm1Df homozygotes

• consistent with rescued ABR thresholds, the developmental expression of the I_K,f potassium current in cochlear IHCs is also largely corrected at P30 relative to single Thrb^tm1Df homozygotes

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