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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rr27tm1Rohl
targeted mutation 1, Rolf Ohlsson
MGI:2653959
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Rr27tm1Rohl/Rr27+ involves: 129S1/Sv * 129X1/SvJ MGI:3722289
ht2
Rr27tm1Rohl/Rr27+ involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7 MGI:3722287
cx3
ApcMin/ApcMin
Rr27tm1Rohl/Rr27+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3722288


Genotype
MGI:3722289
ht1
Allelic
Composition
Rr27tm1Rohl/Rr27+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27tm1Rohl mutation (0 available); any Rr27 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice have longer crypts than wild-type mice

endocrine/exocrine glands
• mice have longer crypts than wild-type mice




Genotype
MGI:3722287
ht2
Allelic
Composition
Rr27tm1Rohl/Rr27+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27tm1Rohl mutation (0 available); any Rr27 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• when the allele is inherited maternally, neonatal weight is increased by 11%

cellular
• when the allele is inherited maternally, imprinting of Igf2 is lost




Genotype
MGI:3722288
cx3
Allelic
Composition
ApcMin/ApcMin
Rr27tm1Rohl/Rr27+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (8 available); any Apc mutation (90 available)
Rr27tm1Rohl mutation (0 available); any Rr27 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop twice as many intestinal and colonic adenomas as in ApcMin homozygotes
• mice develop twice as many colonic adenomas as in ApcMin homozygotes

digestive/alimentary system
• mice have longer crypts than wild-type mice
• mice develop twice as many intestinal and colonic adenomas as in ApcMin homozygotes

endocrine/exocrine glands
• mice have longer crypts than wild-type mice





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory