All Phenotypes Rr27<tm1Rohl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr27^tm1Rohl
targeted mutation 1, Rolf Ohlsson
MGI:2653959

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr27^tm1Rohl/Rr27⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3722289
ht2	Rr27^tm1Rohl/Rr27⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7	MGI:3722287
cx3	Apc^Min/Apc^Min Rr27^tm1Rohl/Rr27⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3722288

Allelic Composition	Rr27^tm1Rohl/Rr27⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27^tm1Rohl mutation (0 available); any Rr27 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

Allelic Composition	Rr27^tm1Rohl/Rr27⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N * SD7

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr27^tm1Rohl mutation (0 available); any Rr27 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased susceptibility to weight gain ( J:82427 )

• when the allele is inherited maternally, neonatal weight is increased by 11%

cellular

abnormal imprinting ( J:82427 )

• when the allele is inherited maternally, imprinting of Igf2 is lost

Allelic Composition	Apc^Min/Apc^Min Rr27^tm1Rohl/Rr27⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Rr27^tm1Rohl mutation (0 available); any Rr27 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:97083 )

• mice develop twice as many intestinal and colonic adenomas as in Apc^Min homozygotes

increased colon adenoma incidence ( J:97083 )

• mice develop twice as many colonic adenomas as in Apc^Min homozygotes

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

increased intestinal adenoma incidence ( J:97083 )

• mice develop twice as many intestinal and colonic adenomas as in Apc^Min homozygotes

increased colon adenoma incidence ( J:97083 )

• mice develop twice as many colonic adenomas as in Apc^Min homozygotes

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:97083 )

• mice have longer crypts than wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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