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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cers1to
toppler
MGI:2653507
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cers1to/Cers1to either: FVB/N or (involves: C3H * C57BL/6J * FVB/N) MGI:3047558
hm2
Cers1to/Cers1to FVB/N-Cers1to MGI:5013639
ht3
Cers1fln/Cers1to involves: BALB/c * C57BL/Ka * FVB/N * NOD MGI:5013636


Genotype
MGI:3047558
hm1
Allelic
Composition
Cers1to/Cers1to
Genetic
Background
either: FVB/N or (involves: C3H * C57BL/6J * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cers1to mutation (1 available); any Cers1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average life span is 8 - 10 months

behavior/neurological
• mutants develop mild tremors by P12 that worsen with age and occur when the mutant is stationary or moving
• mutants develop an ataxic gait around 14 days of age
• mutants develop severely impaired balance and are unable to stand erect needing to use a tripod stance when feeding, grooming, or nursing
• older mutants develop mild petit mal-type seizures

growth/size/body
• mutants are smaller compared to wild-type

nervous system
• older mutants develop mild petit mal-type seizures
• the brain is smaller compared to wild-type
• Purkinje cell loss occurs between P21 and P30 so that by 6 months of age most lobules of the cerebellum have only a few remaining Purkinje cells
• the dendritic arbors of Purkinje cells are shorter and thicker compared to wild-type
• the cerebellum is smaller compared to wild-type although this may be a result of overall decreased body size
• astrocytes appear to be increased in older mutants




Genotype
MGI:5013639
hm2
Allelic
Composition
Cers1to/Cers1to
Genetic
Background
FVB/N-Cers1to
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cers1to mutation (1 available); any Cers1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Purkinje cells exhibit higher order dendritic branching pattern abnormalities compared to in wild-type mice




Genotype
MGI:5013636
ht3
Allelic
Composition
Cers1fln/Cers1to
Genetic
Background
involves: BALB/c * C57BL/Ka * FVB/N * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cers1fln mutation (0 available); any Cers1 mutation (14 available)
Cers1to mutation (1 available); any Cers1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• progressive beginning at 3 weeks of age

nervous system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory