Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
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mortality/aging
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• lethality on a 129/Sv background
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Allelic Composition |
Fancltm1Ceb/Fancltm1Ceb
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Genetic Background |
either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * FVB/N) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
|
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endocrine/exocrine glands
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• few developing follicles
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• greater than 90% of the tubules contained vacuolated sertoli cells but no developing germ cells
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• approximately 1/3 the size of wild-type
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reproductive system
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• depletion evident at 10.25 dpc
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• few developing follicles
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• greater than 90% of the tubules contained vacuolated sertoli cells but no developing germ cells
|
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• approximately 1/3 the size of wild-type
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• uterine horns were pale and thin
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cellular
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• depletion evident at 10.25 dpc
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
|
|
mortality/aging
|
• lethality on a mixed background involving 129/Sv and C57BL/6
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Allelic Composition |
Fanclgcd/Fancltm1Ceb
|
|
Genetic Background |
involves: 129S7/SvEvBrd * C57BL/6J * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation
(0 available);
any
Fancl mutation
(29 available)
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
|
|
mortality/aging
|
• lethality on a 129/Sv background
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation
(0 available);
any
Fancl mutation
(29 available)
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
|
|
mortality/aging
|
• lethality on a mixed background involving 129/Sv and C57BL/6
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fanclgcd mutation
(0 available);
any
Fancl mutation
(29 available)
Fancltm1Ceb mutation
(0 available);
any
Fancl mutation
(29 available)
|
|
|
endocrine/exocrine glands
|
• >90% of seminiferous tubules contained vacuolated sertoli cells
|
|
• approximately 1/3 the size of wild-type
|
reproductive system
|
• deficiency observed at 10.5 dpc
|
|
• >90% of seminiferous tubules contained vacuolated sertoli cells
|
|
• approximately 1/3 the size of wild-type
|
cellular
|
• deficiency observed at 10.5 dpc
|