Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4dtm1Mct mutation
(3 available);
any
Pde4d mutation
(181 available)
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behavior/neurological
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• RS25344-treated mice exhibit earlier recovery than wild-type mice
• however, mice do not sleep longer than wild-type mice and normal response to treatment with roflumilast
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4dtm1Mct mutation
(3 available);
any
Pde4d mutation
(181 available)
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cardiovascular system
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• mice have an increased contractile rate in response to isoproterenol compared to wild-type mice
• treatment with rolipram following isoproterenol does not further alter heart contraction as it does in wild-type mice
• pertussis toxin enhances heart rate in response to isoproterenol
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muscle
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• mice have an increased contractile rate in response to isoproterenol compared to wild-type mice
• treatment with rolipram following isoproterenol does not further alter heart contraction as it does in wild-type mice
• pertussis toxin enhances heart rate in response to isoproterenol
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4dtm1Mct mutation
(3 available);
any
Pde4d mutation
(181 available)
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mortality/aging
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• Background Sensitivity: exacerbated on the 129X1/SvJ background compared to mixed 129P2/OlaHsd and C57BL/6 background; only 9.5% of homozygous null mice are recovered at D30
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4dtm1Mct mutation
(3 available);
any
Pde4d mutation
(181 available)
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Growth comparison of wild type and Pde4dtm1Mct/Pde4dtm1Mct mice
mortality/aging
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• 13.8% of homozygous null mice are recovered at D30
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growth/size/body
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• 30-40% decrease in body weight at 1-2 wks of age relative to wild-type and heterozygous littermates
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• growth rate returns to normal at about 2 wks, though the weight of adult mice remains lower than that of wild-type and heterozygous littermates
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immune system
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• response to LPS and thioglycollate is similar to that in wild-type mice
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• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type
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• 48% reduction in the number of neutrophils that are recruited to the lung following LPS inhalation compared to wild-type and homozygous Pde4a mutants
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• levels of TNF-alpha were significantly reduced at 2 hours after LPS inhalation and remained lower for up to 4 hours compared to controls
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reproductive system
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• impaired ovulation, yielding few oocytes, after administration of gonadotropins; diminished sensitivity of granulosa cells to gonadotropins
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homeostasis/metabolism
cellular
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• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type
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hematopoietic system
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• chemotaxis in response to KC and macrophage-inflammatory protein-2 was reduced in homozygous mutant neutrophils compared to wild-type
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• 48% reduction in the number of neutrophils that are recruited to the lung following LPS inhalation compared to wild-type and homozygous Pde4a mutants
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immune system
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• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type
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hematopoietic system
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• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4b mutants or in wild-type
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mortality/aging
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• do not survive after birth
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immune system
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• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type
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hematopoietic system
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• neutrophil recruitment to the lung following LPS inhalation was decreased more than in single homozygous Pde4d mutants or in wild-type
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Analysis Tools