Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ratm1Koll mutation
(0 available);
any
Il17ra mutation
(46 available)
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immune system
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• IL25 mediated differentiation is impaired in cultured cells
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• recruitment of neutrophils into the peritoneum by IL-17A or IL-17B is severely impaired in these mice
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• cells transduced with an Il17re-expressing retroviral vector exhibit reduced IL17A in response to IL17C compared with similarly treated wild-type cells
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• IL25 application to T cells cultured in Th9 inducing conditions fails to induced IL9 secretion as it does in wild-type cells
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hematopoietic system
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• IL25 mediated differentiation is impaired in cultured cells
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• recruitment of neutrophils into the peritoneum by IL-17A or IL-17B is severely impaired in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17ratm1Koll mutation
(0 available);
any
Il17ra mutation
(46 available)
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homeostasis/metabolism
immune system
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• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae
• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF
• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores
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• numbers became attenuated by 18 hours after infection
• significantly neutropenic by 48hours after infection
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• decreased neutrophil recruitment to the lungs
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• splenocytes fail to secrete IL-13 when incubated in vitro with IL-25
• splenocytes produce significantly more IL-13 than controls when stimulated with Con A
• there are no significant increases in levels of IL-13 found in the bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 unlike in wild-type mice which have significant increases
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• there are no significant increases in levels of IL-5 found in the bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 unlike in wild-type mice which have significant increases
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• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF
• intranasal administration of IL-25 fails to induce histological signs of inflammation with damage scores being essentially normal while wild-type mice treated in the same way have significantly higher scores
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• significantly reduced survival after infection with Klebsiella pneumoniae
• pulmonary growth of bacteria significantly greater than in controls 24 hours after infection
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respiratory system
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• perivascular edema develops in the lungs by 24 hours after infection with K pneumoniae
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hematopoietic system
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• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae
• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF
• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores
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• numbers became attenuated by 18 hours after infection
• significantly neutropenic by 48hours after infection
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• decreased neutrophil recruitment to the lungs
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cellular
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• normal baseline granulopoiesis but a significant decrease after infection with K pneumoniae
• mice do not have increased numbers of inflammatory cells in their bronchoalveolar lavage fluid (BALF) after intranasal challenge with IL-25 while wild-type mice undergoing the same challenge have increased numbers of leukocytes in their BALF
• intranasal administration of IL-25 fails to induce histological signs of inflammation with inflammation scores being essentially normal while wild-type mice treated in the same way have significantly higher scores
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation
(6 available);
any
Apc mutation
(154 available)
Il17ratm1Koll mutation
(0 available);
any
Il17ra mutation
(46 available)
Tg(CDX2-cre)101Erf mutation
(1 available)
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neoplasm
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• reduced colorectal tumor multiplicity and grown compared to in Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
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Analysis Tools