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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igf2rtm1Rlj
targeted mutation 1, Randy L Jirtle
MGI:2447856
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Igf2rtm1Rlj/Igf2r+
Tg(Ckmm-cre)1Lrsn/0
involves: 129 * C57BL/6J MGI:3795377
cn2
Igf2rtm1Rlj/Igf2r+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129/Sv * C57BL/6 * DBA MGI:3795373


Genotype
MGI:3795377
cn1
Allelic
Composition
Igf2rtm1Rlj/Igf2r+
Tg(Ckmm-cre)1Lrsn/0
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Rlj mutation (0 available); any Igf2r mutation (98 available)
Tg(Ckmm-cre)1Lrsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype

cellular
• the paternally-inherited Igf2r allele is normally silenced through genomic imprinting so embryos inheriting the floxed Igf2r allele maternally are functionally muscle-specific homozygous knockouts




Genotype
MGI:3795373
cn2
Allelic
Composition
Igf2rtm1Rlj/Igf2r+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2rtm1Rlj mutation (0 available); any Igf2r mutation (98 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
N
• no histologic differences are detected

normal phenotype
• mice show no significant differences from wild-type in body or organ weights

cellular
• the paternally-inherited Igf2r allele is normally silenced through genomic imprinting so embryos inheriting the floxed Igf2r allele maternally are functionally liver-specific homozygous knockouts





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory