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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Thy1-APP)3Somm
transgene insertion 3, Bernd Sommer
MGI:2447146
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Prnp-ITM2B*)6Jckr/0
Tg(Thy1-APP)3Somm/0
B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm MGI:4452490
cx2
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Thy1-APP)3Somm/0
involves: C57BL/6 * C57BL/6J * DBA/2 MGI:4833965
cx3
Abca1tm1Jdm/Abca1tm1Jdm
Tg(Thy1-APP)3Somm/0
involves: C57BL/6J * DBA/1LacJ * DBA/2 MGI:4833954
tg4
Tg(Thy1-APP)3Somm/0 B6.Cg-Tg(Thy1-APP)3Somm MGI:3720731
tg5
Tg(Thy1-APP)3Somm/0 involves: C57BL/6J * DBA/2 MGI:2652447


Genotype
MGI:4452490
cx1
Allelic
Composition
Tg(Prnp-ITM2B*)6Jckr/0
Tg(Thy1-APP)3Somm/0
Genetic
Background
B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice




Genotype
MGI:4833965
cx2
Allelic
Composition
Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tg(Thy1-APP)3Somm/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APP)3Somm mutation (0 available)
Tnfrsf1atm1Imx mutation (4 available); any Tnfrsf1a mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• at 24 months, mice exhibit little neuronal loss unlike Tg(Thy1-APP)3Somm mice
• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice
• at 24 months, mice exhibit reduced amyloid plaques compared with Tg(Thy1-APP)3Somm mice
• mice exhibit reduced cerebral amyloid angiopathy compared with Tg(Thy1-APP)3Somm mice

behavior/neurological
N
• mice exhibit normal exploratory learning and memory retention unlike Tg(Thy1-APP)3Somm mice

hematopoietic system
• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice

immune system
• mice exhibit less microglial activation compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
• at 24 months, mice exhibit reduced amyloid plaques compared with Tg(Thy1-APP)3Somm mice
• mice exhibit reduced cerebral amyloid angiopathy compared with Tg(Thy1-APP)3Somm mice




Genotype
MGI:4833954
cx3
Allelic
Composition
Abca1tm1Jdm/Abca1tm1Jdm
Tg(Thy1-APP)3Somm/0
Genetic
Background
involves: C57BL/6J * DBA/1LacJ * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jdm mutation (1 available); any Abca1 mutation (43 available)
Tg(Thy1-APP)3Somm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

nervous system
• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice
• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice

cardiovascular system
• mice exhibit more cerebral amyloid angiopathy-associated cerebral hemorrhage than Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
• mice exhibit a 2-fold increase in insoluble beta-amyloid in the brain compared with Tg(Thy1-APP)3Somm mice
• at 13 months, mice exhibit more cerebral amyloid angiopathy than in Tg(Thy1-APP)3Somm mice




Genotype
MGI:3720731
tg4
Allelic
Composition
Tg(Thy1-APP)3Somm/0
Genetic
Background
B6.Cg-Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons
• axons that line the periphery of beta-amyloid plaques exhibit swelling unlike in wild-type mice
• entorhinal fibers extend outside the termination zone unlike in wild-type mice
• commissure axons extend into the outer molecular layer unlike in wild-type mice
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

behavior/neurological
• at 3 months, mice exhibit lower light ambulation compared with wild-type mice
• at 6 months, mice exhibit increased in the ratio of dark to light ambulation during the second half of the active phase compared with wild-type mice
• at 12 months, circadian locomotor patterns are more constant than in wild-type mice
• at 12 months, mice exhibit increased dark and total ambulation compared with wild-type mice
• at 12 months, dark ambulation level is bimodal unlike in wild-type mice
• at 6 months during the first 2 hours
• impaired acquisition in the Morris water maze; the number of quadrant entries and the escape latencies are higher than in controls
• however, mutants are unaffected in open-field, elevated plus-maze, emergence tests, tests measuring motor coordination, during the probe trial and while swimming towards a visible platform
• in an isolation-induced/resident-intruder paradigm, mice exhibit a 4.6- and 59-fold increase in aggression at 6 and 12 months, respectively, compared with wild-type mice
• 67% of animals exhibit myoclonic jumping behavior in home cage
• reduced number of horizontal and vertical movements in the photocell monitor
• overnight at 12 months

growth/size/body
• 29% weight reduction compared to wild-type

homeostasis/metabolism
• amyloid plaques are associated with alterations in axonal growth and ectopic synaptic differentiation
• vascular amyloid is associated with ectopic entorhinal boutons

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:80449




Genotype
MGI:2652447
tg5
Allelic
Composition
Tg(Thy1-APP)3Somm/0
Genetic
Background
involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)
• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)
• develop almost exclusively congophilic plaques already at their first appearance (J:44603)
• at 24 months (J:134832)
• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)
• mutants exhibit inflammatory responses in the brain, showing a massive glial response
• loss of pyramidal neurons in the vicinity of amyloid beta deposits in the CA3 area
• local distortion of the cholinergic fiber network is seen in the vicinity of plaques
• local loss of neurons in the vicinity of plaques
• at 24 months

immune system
• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice
• mutants exhibit inflammatory responses in the brain, showing a massive glial response

cardiovascular system
• mice exhibit aneurysm-like vasodilation unlike in wild-type mice
• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice
• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice
• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice
• mice exhibit blood vessel ruptures that range from microhemorrhages to large hematomas unlike wild-type mice
• mice exhibit leakage in the blood-brain barrier unlike wild-type mice
• mice exhibit cerebral amyloid angiopathy associated vasculitis unlike wild-type mice

muscle
• mice exhibit smooth muscle cell degeneration in amyloid laden blood vessels unlike wild-type mice

homeostasis/metabolism
• bicuculline-treated mice exhibit delayed and reduced amplitude of changes in cerebral blood volume compared with similarly treated wild-type mice
• at 25 months, acetazolamide-treated mice exhibit a smaller increase in the percent change of cerebral blood volume compared with similarly treated wild-type mice
• during posthypoxic recovery, the spike amplitude in hippocampal region CA1 after stimulation of Schaffer collaterals in region CA3 is less than in similarly treated wild-type mice
• at 4 months, hypoxic tolerance is impaired compared to in similarly treated wild-type mice
• develop amyloid beta deposits in the neocortex and hippocampus starting at 6 months of age, which increase in size and number with age (J:44603)
• by 24 months of age, deposits occupy a substantial area of the neocortex and hippocampus and are found in the thalamus and olfactory nucleus and are isolated in the caudate putamen (J:44603)
• develop almost exclusively congophilic plaques already at their first appearance (J:44603)
• at 24 months (J:134832)
• in the neocortex, hippocampus, and thalamus and to a lesser degree in other regions such as septum, striatum, brainstem, and white matter (J:67583)

behavior/neurological
• at 6 months, mice exhibit reduced exploratory learning compared with wild-type mice
• object recognition is impaired compared to in wild-type mice

hematopoietic system





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory