Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-Hras1)2Agu
• Allele Name: transgene insertion 2, Abhijit Guha
• Allele ID: MGI:2445442
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:5286097
tg2	Tg(GFAP-Hras1)2Agu/0	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:5286096

Genotype
MGI:5286097

tg1

• Allelic Composition: Tg(GFAP-Hras1)2Agu/Tg(GFAP-Hras1)2Agu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:69129 )

• mice begin to die at 2 months of age

• 50% of mice die by 3 months of age

• mice die by 4 to 6 months of age

nervous system

increased astrocytoma incidence ( J:69129 )

• at 3 weeks with trisomies

hydrocephaly ( J:69129 )

abnormal astrocyte morphology ( J:69129 )

• mild, widespread astrocytic hyperplasia

neoplasm

increased astrocytoma incidence ( J:69129 )

• at 3 weeks with trisomies

behavior/neurological

ataxia ( J:69129 )

cellular

trisomy ( J:69129 )

• 88% of astrocytoma cells exhibit trisomies

growth/size/body

postnatal growth retardation ( J:69129 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:69129
malignant astrocytoma		DOID:3069		J:69129

Genotype
MGI:5286096

tg2

• Allelic Composition: Tg(GFAP-Hras1)2Agu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

mortality/aging

premature death ( J:69129 )

• 50% of mice die by 4 weeks of age

neoplasm

increased astrocytoma incidence ( J:69129 )

• at 12 weeks

nervous system

increased astrocytoma incidence ( J:69129 )

• at 12 weeks