Phenotypes associated with this allele

• Allele Symbol: Cpb2^tm1Efp
• Allele Name: targeted mutation 1, Edward F Plow
• Allele ID: MGI:2445419
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpb2^tm1Efp/Cpb2^tm1Efp	B6.129-Cpb2^tm1Efp	MGI:3720814
cx2	Cpb2^tm1Efp/Cpb2^tm1Efp Plg^tm1Dco/Plg^tm1Dco	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720815
cx3	Cpb2^tm1Efp/Cpb2^+ Plg^tm1Dco/Plg^tm1Dco	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720818
cx4	Cpb2^tm1Efp/Cpb2^+ Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720825
cx5	Cpb2^tm1Efp/Cpb2^tm1Efp Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720826

Genotype
MGI:3720814

hm1

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp
• Genetic Background: B6.129-Cpb2^tm1Efp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrin clot digestion is 52.8%+/-1.8% compared to 49.0%+/-1.5% in wild-type extracts and fails to increase with the addition of a potato carboxypeptidase inhibitor (PCI) as in wild-type extracts

Genotype
MGI:3720815

cx2

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp; Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased to 54.9%+/-3.7% compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes

growth/size/body

decreased body size ( J:80114 )

• mice are runted and have persistent health problems described for Plg^tm1Dco homozygotes

Genotype
MGI:3720818

cx3

• Allelic Composition: Cpb2^tm1Efp/Cpb2⁺; Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity exhibits an intermediate increase to 29.3%+/-3.4% compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes and 54.9%+/-3.7% in Cpb2^tm1Efp Plg^tm1Dco homozygotes

Genotype
MGI:3720825

cx4

• Allelic Composition: Cpb2^tm1Efp/Cpb2⁺; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (23.8+/-2.1 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3720826

cx5

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes and in Cpb2^tm1Efp Plg^tm1Dco heterozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (29.5+/-2.7 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)