Analysis Tools
homeostasis/metabolism
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• about a 4-fold increase in the plasma level of soluble SELP
(J:51068)
• about a 2 fold increase in the total number of microparticles in the plasma compared to controls
(J:125020)
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• shorter plasma clotting time compared to controls
• excess deposition of fibrin when non-anticoagulated blood is passed through glass capillaries coated with fibrillar collagen type III
• however, no significant differences in fibrinogen levels are detected compared to controls
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immune system
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• no increase in the number of rolling leukocytes is seen after stimulation with a calcium ionophore
• however, in the absence of stimulation rolling is similar to controls
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• at 2 h after peritoneal thioglycollate injection neutrophil influx is only 30% that of wild-type controls
• however, by 4 h after injection neutrophil numbers are similar to controls
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cardiovascular system
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• in all pulmonary endothelial cells and some brain microvascular endothelial cells the mutant protein is localized to the membrane rather than in Weibel-Palade bodies as in wild type cells
• however, in some endothelial cells from brain microvasculature the mutant protein is localized to Weibel-Palade bodies
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hemorrhage
(
J:125020
)
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• about a 50% reduction in average hemorrhagic lesion size following induced local Shwartzman reaction compared to wild-type controls
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cellular
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• no increase in the number of rolling leukocytes is seen after stimulation with a calcium ionophore
• however, in the absence of stimulation rolling is similar to controls
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hematopoietic system
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• no increase in the number of rolling leukocytes is seen after stimulation with a calcium ionophore
• however, in the absence of stimulation rolling is similar to controls
|
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• at 2 h after peritoneal thioglycollate injection neutrophil influx is only 30% that of wild-type controls
• however, by 4 h after injection neutrophil numbers are similar to controls
|
