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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(RIP1-Tag)2Dh
transgene insertion 2, Douglas Hanahan
MGI:2429941
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Ins2-cre)1Heed/?
Tg(RIP1-Tag)2Dh/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J MGI:3715012
cn2
Itgb1tm4Ref/Itgb1tm4Ref
Tg(Ins2-cre)1Heed/?
Tg(RIP1-Tag)2Dh/?
involves: C57BL/6 * C57BL/6J * CBA * DBA/2J MGI:3715016
cx3
Itgb1tm1Ref/Itgb1tm1Ref
Tg(RIP1-Tag)2Dh/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J MGI:3715015
cx4
Fn1tm1Bwg/Fn1tm1Bwg
Tg(RIP1-Tag)2Dh/0
involves: 129S4/SvJae * BALB/c * C57BL/6J MGI:3056920
cx5
Fn1tm1Ksek/Fn1tm1Ksek
Tg(RIP1-Tag)2Dh/0
involves: 129S4/SvJae * C57BL/6J MGI:3056922
cx6
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3843604
cx7
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3843606
cx8
Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/?
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J MGI:3718021
cx9
Plautm1Mlg/Plautm1Mlg
Tg(RIP1-Tag)2Dh/0
involves: C57BL/6 MGI:3527475
tg10
Tg(RIP1-Tag)2Dh/0 involves: C57BL/6 MGI:4821099
tg11
Tg(RIP1-Tag)2Dh/0 involves: C57BL/6J * DBA/2J MGI:5431966
tg12
Tg(RIP1-Tag)2Dh/? C3.Cg-Tg(RIP1-Tag)2Dh MGI:3757564


Genotype
MGI:3715012
cn1
Allelic
Composition
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Ins2-cre)1Heed/?
Tg(RIP1-Tag)2Dh/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (27 available)
Tg(Ins2-cre)1Heed mutation (0 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• derived cells have fewer projections
• derived cell lines exhibit decreased binding to collagen IV
• more derived tumor cells are arrested in G0/G1 than in Itgb1tm1Ref Tg(RIP1-Tag)2Dh controls
• cultured cells die within a week after plating compared to Itgb1tm1Ref Tg(RIP1-Tag)2Dh derived cells
• more derived tumor cells are arrested in G0/G1 than in Itgb1tm1Ref Tg(RIP1-Tag)2Dh controls

neoplasm
• when derived cell lines are injected into nu/nu mice, metastatic nodules from do not form in the lungs and or liver as they do in wild-type mice
• however, no metastasis is detected in mice with tumors
• 60% of mice have an increase in the number of disseminated tumor cell emboli within lymphatic vessels near tumors compared to 7.7% in Itgb1tm1Ref Tg(RIP1-Tag)2Dh mice
• tumor volume is reduced compared to that in Itgb1tm1Ref Tg(RIP1-Tag)2Dh mice
• tumor cell proliferation is significantly reduced and apoptotic rate is reduced compared to Itgb1tm1Ref Tg(RIP1-Tag)2Dh mice




Genotype
MGI:3715016
cn2
Allelic
Composition
Itgb1tm4Ref/Itgb1tm4Ref
Tg(Ins2-cre)1Heed/?
Tg(RIP1-Tag)2Dh/?
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm4Ref mutation (0 available); any Itgb1 mutation (27 available)
Tg(Ins2-cre)1Heed mutation (0 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• similar to Itgb1tm1Ref Tg(Ins2-cre)1Heed Tg(RIP1-Tag)2Dh, mice exhibit reduced tumor burden and increased tumor cell embolization in the lymphatics




Genotype
MGI:3715015
cx3
Allelic
Composition
Itgb1tm1Ref/Itgb1tm1Ref
Tg(RIP1-Tag)2Dh/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (27 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 7.7% of mice have an increase in the number of disseminated tumor cell emboli within lymphatic vessels near tumors
• however, no metastasis is detected in mice with tumors




Genotype
MGI:3056920
cx4
Allelic
Composition
Fn1tm1Bwg/Fn1tm1Bwg
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1tm1Bwg mutation (1 available); any Fn1 mutation (60 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• the number of angiogenic islets and tumor progression are not different from Tg(RIP1-Tag)2Dh hemizygotes

cardiovascular system
N
• no difference in tumor angiogenesis is seen




Genotype
MGI:3056922
cx5
Allelic
Composition
Fn1tm1Ksek/Fn1tm1Ksek
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1tm1Ksek mutation (1 available); any Fn1 mutation (60 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• the number of angiogenic islets and tumor progression are not different from Tg(RIP1-Tag)2Dh hemizygotes

cardiovascular system
N
• no difference in tumor angiogenesis is seen




Genotype
MGI:3843604
cx6
Allelic
Composition
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(Ins2-cre)25Mgn/0
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (120 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm3
• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

neoplasm
• 13 week old mice have a mean of over 4 tumors with an average volume greater than 50 mm3
• there is a significantly higher proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics (22.8% vs. 4.3%)

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:146436




Genotype
MGI:3843606
cx7
Allelic
Composition
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1.1Mam mutation (0 available); any Bcl2l1 mutation (120 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

neoplasm
• 13 week old mice have a mean of 7 tumors with an average volume greater than 40 mm3
• there is a significantly lower proportion of encapsulated, non-invasive tumors in these mice compared to Tg(RIP1-Tag)2Dh transgenics where cre-mediated recombination of Bcl2l1 occurs in pancreatic beta cells

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:146436




Genotype
MGI:3718021
cx8
Allelic
Composition
Mfge8tm1Mcu/Mfge8tm1Mcu
Tg(RIP1-Tag)2Dh/?
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfge8tm1Mcu mutation (0 available); any Mfge8 mutation (9 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice have a 20% reduction in tumor vessel permeability compared to in Tg(RIP1-Tag)2Dh transgenic mice
• at 12 and 13.5 weeks of age, tumor burden is decreased 2-fold tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
• tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice
• there is a decrease in invasive type 2 tumors compared to in Tg(RIP1-Tag)2Dh transgenic mice
• adenoma incidence are increased compared to in Tg(RIP1-Tag)2Dh transgenic mice
• apoptotic cells are less frequent in adenomas compared to in hyperblastic and angiogenic islet cells in the same animals and in Tg(RIP1-Tag)2Dh transgenic mice
• there is a two-fold increase in apoptosis in microinvasive carcinomas

hematopoietic system
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice

immune system
• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice
• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice




Genotype
MGI:3527475
cx9
Allelic
Composition
Plautm1Mlg/Plautm1Mlg
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plautm1Mlg mutation (3 available); any Plau mutation (10 available)
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 13.5 weeks (end stage), mice homozygous for Plautm1Mlg and hemizygous for Tg(RIP1-Tag)2Dh show no differences in the number of angiogenic islets or collective tumor growth relative to Tg(RIP1-Tag)2Dh hemizygotes

cardiovascular system
N
• at 10.5 weeks of age, mice homozygous for Plautm1Mlg and hemizygous for Tg(RIP1-Tag)2Dh show no differences in the frequency of angiogenic switching among premalignant islets relative to RIP1-Tag2 hemizygotes




Genotype
MGI:4821099
tg10
Allelic
Composition
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• average tumor volume at 12 weeks of age is about 36 mm cubed

mortality/aging
• average lifespan is about 12.6 weeks

neoplasm
• average tumor volume at 12 weeks of age is about 36 mm cubed




Genotype
MGI:5431966
tg11
Allelic
Composition
Tg(RIP1-Tag)2Dh/0
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die at 9-12 weeks of age; almost complete penetrance
• mutants placed on a high sugar diet to counteract hypoglycemia liver longer

endocrine/exocrine glands
• hyperplasia of the islets of Langerhans
• organization of alpha and delta cells is disrupted in islets
• reduced numbers of alpha cells in islets
• islets are densely packed with beta-cells
• reduced numbers of delta cells in islets
• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors
• no evidence that tumors metastasize other organs

neoplasm
• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors
• no evidence that tumors metastasize other organs

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Pancreatic Cancer 260350 J:50695




Genotype
MGI:3757564
tg12
Allelic
Composition
Tg(RIP1-Tag)2Dh/?
Genetic
Background
C3.Cg-Tg(RIP1-Tag)2Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(RIP1-Tag)2Dh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transgenic mice develop pancreatic beta cell tumors

neoplasm
• transgenic mice develop pancreatic beta cell tumors





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory