Phenotypes associated with this allele

• Allele Symbol: F2rl1^tm1Mslb
• Allele Name: targeted mutation 1, Mary Stevens
• Allele ID: MGI:2389587
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F2rl1^tm1Mslb/F2rl1^tm1Mslb	involves: 129X1/SvJ * C57BL/6	MGI:3784837

Genotype
MGI:3784837

hm1

• Allelic Composition: F2rl1^tm1Mslb/F2rl1^tm1Mslb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgE level ( J:79757 )

• following sensitization with ovalbumin and exposure to ovalbumin, IgE levels are 4-fold lower than in similarly trated wild-type mice

decreased inflammatory response ( J:79757 )

• following sensitization with ovalbumin and exposure to ovalbumin, mice exhibit a 64% reduction in cellular inflammatory infiltrate in bronchoalveolar lavage (specifically, 73% less eosinophils, 71% less neutrophils, 49% less macrophages, and 59% less lymphocytes) compared to in similarly treated wild-type mice

• however, cellular composition of the inflammatory infiltrate is normal

hematopoietic system

decreased IgE level ( J:79757 )

• following sensitization with ovalbumin and exposure to ovalbumin, IgE levels are 4-fold lower than in similarly trated wild-type mice