About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr132tm1Witt
targeted mutation 1, Owen N Witte
MGI:2388138
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr132tm1Witt/Gpr132tm1Witt B6.129X1-Gpr132tm1Witt MGI:3576045
hm2
 		Gpr132tm1Witt/Gpr132tm1Witt involves: 129X1/SvJ * BALB/c MGI:3639677
cx3
 		Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her 		B6.129-Ldlrtm1Her Gpr132tm1Witt MGI:3639678


Genotype
MGI:3576045
hm1
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background		 B6.129X1-Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline

cellular
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline

hematopoietic system
impaired macrophage chemotaxis ( J:96613 )
• no macrop[hage migration in response to lysophosphatidyl choline




Genotype
MGI:3639677
hm2
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background		 involves: 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
increased immunoglobulin level ( J:69473 )
• kappa and lambda light chain levels elevated
increased IgA level ( J:69473 )
• in older mice
increased IgG1 level ( J:69473 )
• elevated IgG1 levels in older mice
abnormal immune system organ morphology ( J:69473 )
• although normal in young mice, after 1 year of age, secondary lymph nodes become grossly enlarged
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes
abnormal lymph node morphology ( J:69473 )
• disrupted architecture
• 3-6X increase of single positive T lymphocytes
• 2-3X increase of B220+ B lymphocytes
enlarged inguinal lymph nodes ( J:69473 )
• rarely is enlarged in young mice
increased anti-nuclear antigen antibody level ( J:69473 )
• increased autoantibodies to nuclear antigens
increased inflammatory response ( J:69473 )
• heavy infiltration of lymphocytes into various organs in older mice
liver inflammation ( J:69473 )
• clusters of lymphocytes in liver parenchyma
kidney inflammation ( J:69473 )
• immunoglobulin complex deposited in glomeruli
lung inflammation ( J:69473 )
• perivascular and interalveolar infiltration of mononuclear cells

growth/size/body
cachexia ( J:69473 )
• start to show signs of wasting at 15-16 months of age
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes

hematopoietic system
enlarged spleen ( J:69473 )
• expanded numbers of T and B lymphocytes
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
increased immunoglobulin level ( J:69473 )
• kappa and lambda light chain levels elevated
increased IgA level ( J:69473 )
• in older mice
increased IgG1 level ( J:69473 )
• elevated IgG1 levels in older mice

liver/biliary system
liver inflammation ( J:69473 )
• clusters of lymphocytes in liver parenchyma

respiratory system
lung inflammation ( J:69473 )
• perivascular and interalveolar infiltration of mononuclear cells

renal/urinary system
kidney inflammation ( J:69473 )
• immunoglobulin complex deposited in glomeruli

cellular
increased B cell proliferation ( J:69473 )
• hyperresponsive to surface IgM crosslinking agents
increased T cell proliferation ( J:69473 )
• enhanced proliferative response to T cell receptor stimulation, even in younger mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autoimmune disease DOID:417 OMIM:109100
 J:69473




Genotype
MGI:3639678
cx3
Allelic
Composition		 Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background		 B6.129-Ldlrtm1Her Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (23 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:100498 )
• area in lesions occupied by macrophage is significantly increased
• reduced collagen content
• decreased apoptosis of macrophage in lesions

immune system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

cellular
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions

hematopoietic system
decreased macrophage apoptosis ( J:100498 )
• decreased apoptosis of macrophage in atherosclerotic lesions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory