Mouse Genome Informatics
hm1
    Gpr132tm1Witt/Gpr132tm1Witt
B6.129X1-Gpr132tm1Witt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• no macrop[hage migration in response to lysophosphatidyl choline

cellular
• no macrop[hage migration in response to lysophosphatidyl choline

hematopoietic system
• no macrop[hage migration in response to lysophosphatidyl choline


Mouse Genome Informatics
hm2
    Gpr132tm1Witt/Gpr132tm1Witt
involves: 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• hyperresponsive to surface IgM crosslinking agents
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
• kappa and lambda light chain levels elevated
• in older mice
• elevated IgG1 levels in older mice
• although normal in young mice, after 1 year of age, secondary lymph nodes become grossly enlarged
• expanded numbers of T and B lymphocytes
• disrupted architecture
• 3-6X increase of single positive T lymphocytes
• 2-3X increase of B220+ B lymphocytes
• rarely is enlarged in young mice
• increased autoantibodies to nuclear antigens
• heavy infiltration of lymphocytes into various organs in older mice
• clusters of lymphocytes in liver parenchyma
• immunoglobulin complex deposited in glomeruli
• perivascular and interalveolar infiltration of mononuclear cells

growth/size/body
• start to show signs of wasting at 15-16 months of age

hematopoietic system
• expanded numbers of T and B lymphocytes
• hyperresponsive to surface IgM crosslinking agents
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
• kappa and lambda light chain levels elevated
• in older mice
• elevated IgG1 levels in older mice

liver/biliary system
• clusters of lymphocytes in liver parenchyma

respiratory system
• perivascular and interalveolar infiltration of mononuclear cells

renal/urinary system
• immunoglobulin complex deposited in glomeruli

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Disease 109100 J:69473


Mouse Genome Informatics
cx3
    Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her

B6.129-Ldlrtm1Her Gpr132tm1Witt
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• area in lesions occupied by macrophage is significantly increased
• reduced collagen content
• decreased apoptosis of macrophage in lesions

immune system
• decreased apoptosis of macrophage in atherosclerotic lesions

cellular
• decreased apoptosis of macrophage in atherosclerotic lesions

hematopoietic system
• decreased apoptosis of macrophage in atherosclerotic lesions