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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr132tm1Witt
targeted mutation 1, Owen N Witte
MGI:2388138
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpr132tm1Witt/Gpr132tm1Witt B6.129X1-Gpr132tm1Witt MGI:3576045
hm2
Gpr132tm1Witt/Gpr132tm1Witt involves: 129X1/SvJ * BALB/c MGI:3639677
cx3
Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
B6.129-Ldlrtm1Her Gpr132tm1Witt MGI:3639678


Genotype
MGI:3576045
hm1
Allelic
Composition
Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background
B6.129X1-Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no macrop[hage migration in response to lysophosphatidyl choline

cellular
• no macrop[hage migration in response to lysophosphatidyl choline

hematopoietic system
• no macrop[hage migration in response to lysophosphatidyl choline




Genotype
MGI:3639677
hm2
Allelic
Composition
Gpr132tm1Witt/Gpr132tm1Witt
Genetic
Background
involves: 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• hyperresponsive to surface IgM crosslinking agents
• kappa and lambda light chain levels elevated
• in older mice
• elevated IgG1 levels in older mice
• enhanced proliferative response to T cell receptor stimulation, even in younger mice
• although normal in young mice, after 1 year of age, secondary lymph nodes become grossly enlarged
• expanded numbers of T and B lymphocytes
• disrupted architecture
• 3-6X increase of single positive T lymphocytes
• 2-3X increase of B220+ B lymphocytes
• rarely is enlarged in young mice
• increased autoantibodies to nuclear antigens
• heavy infiltration of lymphocytes into various organs in older mice
• clusters of lymphocytes in liver parenchyma
• immunoglobulin complex deposited in glomeruli
• perivascular and interalveolar infiltration of mononuclear cells

growth/size/body
• start to show signs of wasting at 15-16 months of age

hematopoietic system
• expanded numbers of T and B lymphocytes
• hyperresponsive to surface IgM crosslinking agents
• kappa and lambda light chain levels elevated
• in older mice
• elevated IgG1 levels in older mice
• enhanced proliferative response to T cell receptor stimulation, even in younger mice

liver/biliary system
• clusters of lymphocytes in liver parenchyma

respiratory system
• perivascular and interalveolar infiltration of mononuclear cells

renal/urinary system
• immunoglobulin complex deposited in glomeruli

Mouse Models of Human Disease
OMIM ID Ref(s)
Autoimmune Disease 109100 J:69473




Genotype
MGI:3639678
cx3
Allelic
Composition
Gpr132tm1Witt/Gpr132tm1Witt
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
B6.129-Ldlrtm1Her Gpr132tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr132tm1Witt mutation (1 available); any Gpr132 mutation (8 available)
Ldlrtm1Her mutation (19 available); any Ldlr mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• area in lesions occupied by macrophage is significantly increased
• reduced collagen content
• decreased apoptosis of macrophage in lesions

immune system
• decreased apoptosis of macrophage in atherosclerotic lesions

cellular
• decreased apoptosis of macrophage in atherosclerotic lesions

hematopoietic system
• decreased apoptosis of macrophage in atherosclerotic lesions





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory