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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1tm1Jrc
targeted mutation 1, J Richard Chaillet
MGI:2387992
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt1tm1Jrc/Dnmt1tm1Jrc involves: 129S1/Sv MGI:3795496
hm2
 		Dnmt1tm1Jrc/Dnmt1tm1Jrc involves: 129S1/Sv * FVB/N MGI:3795495


Genotype
MGI:3795496
hm1
Allelic
Composition		 Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jrc mutation (0 available); any Dnmt1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
female infertility ( J:68455 )
• female mice are infertile and fail to produce embryos that survive beyond early fetal or neonatal development

cellular
abnormal imprinting ( J:68455 )
• heterozygous offspring of homozygous female mice exhibit abnormal imprinting
• however, global methylation is unchanged




Genotype
MGI:3795495
hm2
Allelic
Composition		 Dnmt1tm1Jrc/Dnmt1tm1Jrc
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jrc mutation (0 available); any Dnmt1 mutation (108 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal imprinting ( J:135338 )
• differential methylation patterns are not maintained unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory