All Phenotypes Nudt1<tm1Tts> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nudt1^tm1Tts/Nudt1^tm1Tts	B6.129S-Nudt1^tm1Tts	MGI:3784585
hm2	Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:3055984
hm3	Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476989
cx4	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun	MGI:5476986
cx5	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6J	MGI:2653017
cx6	Msh2^tm1Tts/Msh2^tm1Tts Nudt1^tm1Tts/Nudt1^tm1Tts	involves: 129S/SvEv * C57BL/6J	MGI:3784584
cx7	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun	involves: 129S/SvEv * C57BL/6JJcl	MGI:5476988

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	B6.129S-Nudt1^tm1Tts

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:79732 )

• G:C->A:T transversions are increased in frequency compared to Nudt-null mice

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased stomach tumor incidence ( J:71836 )

• lesions of the glandular stomach are 3 times as frequent as in controls

• adenomatous hyperplasia, adenomas, and adenocarcinoma

increased liver tumor incidence ( J:71836 )

• liver tumors in 38% of males as opposed to 13% of control males

• liver tumors in 3.9% of females as opposed to none in female controls

increased lung adenoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

increased lung adenocarcinoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

digestive/alimentary system

increased stomach tumor incidence ( J:71836 )

• lesions of the glandular stomach are 3 times as frequent as in controls

• adenomatous hyperplasia, adenomas, and adenocarcinoma

respiratory system

increased lung adenoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

increased lung adenocarcinoma incidence ( J:71836 )

• found in greater numbers at age 1.5 years

liver/biliary system

increased liver tumor incidence ( J:71836 )

• liver tumors in 38% of males as opposed to 13% of control males

• liver tumors in 3.9% of females as opposed to none in female controls

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:193978 )

N	• 3-NP-treated mice exhibit normal distance traveled in an open-field test

Allelic Composition	Mutyh^tm1Yun/Mutyh^tm1Yun Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	B6JJcl.129-Mutyh^tm1Yun Nudt1^tm1Tts Ogg1^tm1Yun

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mutyh^tm1Yun mutation (2 available); any Mutyh mutation (36 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:193978 )

• mice are highly susceptible to spontaneous tumorigenesis within 100 days of birth

Allelic Composition	Nudt1^tm1Tts/Nudt1^tm1Tts Ogg1^tm1Yun/Ogg1^tm1Yun
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)
Ogg1^tm1Yun mutation (1 available); any Ogg1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:82287 )

N	• no tumors in the lungs of double knockout mice, unlike Ogg^tm1Skmi single knockout mice

Allelic Composition	Msh2^tm1Tts/Msh2^tm1Tts Nudt1^tm1Tts/Nudt1^tm1Tts
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Tts mutation (0 available); any Msh2 mutation (95 available)
Nudt1^tm1Tts mutation (0 available); any Nudt1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:79732 )

• spleen cells show a significant increase in frameshift mutations at mononucleotide runs relative to wild-type when assayed with a reporter system

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

neurodegeneration ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:193978 )

• 3-NP treated mice exhibit increased motor impairment (neurological score based on: general slowness of displacement resulting from mild hindlimb impairment;, incoordination and marked gait abnormality; hindlimb paralysis; incapacity to move resulting from forelimb and hindlimb impairment) compared with wild-type mice

decreased vertical activity ( J:193978 )

• in 3-NP-treated mice

decreased locomotor activity ( J:193978 )

• 3-NP-treated mice travel less distance in an open-field test compared with wild-type mice that is more severe than in Ogg1^tm1Skmi homozygotes

• 3-NP-treated mice are hypoactive in home cages compared with wild-type mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

cellular

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

• 3-NP treated mice exhibit an accumulation of 8-oxoG that results in the accumulation of single strand breaks in mitochondrial DNA of striatal medium spiny neurons and nuclear DNA of striatal microglia compared with wild-type mice

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:193978 )

• striatal degeneration in 3-NP-treated mice

• however, calpain and PARP inhibitors suppress striatal neurodegeneration and behavioral impairments

abnormal single-strand DNA break repair ( J:193978 )

immune system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

hematopoietic system

microgliosis ( J:193978 )

• in 3-NP-treated mice, especially in the dorsal striatum

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23