Mouse Genome Informatics
hm1
    Prnptm2Edin/Prnptm2Edin
B6.129P2-Prnptm2Edin
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells

cellular
• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells


Mouse Genome Informatics
ht2
    Prnptm1Tuzi/Prnptm2Edin
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• no signs of TSE disease are seen 410 days postinfection an increased incubation time compared to wild-type mice or mutants with cre recombination


Mouse Genome Informatics
ht3
    Prnptm2Tuzi/Prnptm2Edin
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• an increased incubation time for TSE strain ME7 compared to wild-type mice
• this incubation time is similar to that for Prnptm2Edin heterozygotes


Mouse Genome Informatics
cn4
    Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice


Mouse Genome Informatics
cn5
    Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?

involves: 129P2/OlaHsd * BALB/cJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination


Mouse Genome Informatics
cx6
    Prnptm2Edin/Prnptm2Edin
Tg(APPswe,PSEN1dE9)85Dbo/0

B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• unlike transgenic mice wild-type for Prnp, life span is similar to wild-type in transgenic mice null for Prnp (J:160557)

behavior/neurological
N
• unlike transgenic mice wild-type for Prnp, spatial learning and passive avoidance behavior are similar to controls in transgenic mice null for Prnp (J:160557)

nervous system
N
• unlike transgenic mice wild-type for Prnp, axon degeneration and synapse loss are not seen in transgenic mice null for Prnp (J:160557)
• plaque burdens are minimally different from transgenic mice wild-type for Prnp
• astrogliosis is similar to transgenic mice wild-type for Prnp

homeostasis/metabolism
• plaque burdens are minimally different from transgenic mice wild-type for Prnp


Mouse Genome Informatics
cx7
    Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0

B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells

cellular
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells