Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Myl2tm1(cre)Krc mutation
(2 available);
any
Myl2 mutation
(22 available)
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mortality/aging
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• transthoracic arotic banding results in a significant increase in mortality (70%) versus wild-type (10%)
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cardiovascular system
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• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged
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• increase in apoptosis in the ventricles
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• decrease in LV septal thickness
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• decrease in LV posterior wall thickness
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• mutants display relatively normal function at 6 weeks of age and progressively acquire features of cardiomyopathy over a 6-month period
• exhibit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio
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• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure
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• reduction in left ventricle dP/dt min indicates impaired left ventricle relaxation
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muscle
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• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged
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• mutants display relatively normal function at 6 weeks of age and progressively acquire features of cardiomyopathy over a 6-month period
• exhibit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio
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• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure
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• reduction in left ventricle dP/dt min indicates impaired left ventricle relaxation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation
(0 available);
any
Erbb2 mutation
(59 available)
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Gfra1tm3Jmi mutation
(0 available);
any
Gfra1 mutation
(31 available)
Myf5tm3(cre)Sor mutation
(1 available);
any
Myf5 mutation
(17 available)
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nervous system
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• the number of cholinergic motor neurons is decreased compared to in wild-type mice
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• the number of cholinergic motor neurons is decreased compared to in wild-type mice
• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice
• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3tm1Jmi homozygotes
• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation
(0 available);
any
Erbb2 mutation
(59 available)
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Myf5tm3(cre)Sor mutation
(1 available);
any
Myf5 mutation
(17 available)
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behavior/neurological
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• mice show a flexed posture when inverted
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• mice exhibit a wide-based, ataxic gait
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nervous system
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• only rudimentary muscle spindles with a single Egr3-positive myofiber are seen in tibialis anterior muscles at P3 in contrast to spindles in controls which have multiple Egr3+ intrafusal myofibers
• on P4 muscle spindles, few mutant spindles have the complex annulospiral afferent terminal seen around the equatorial region of intrafusal myofibers in control muscle; muscle spindle afferent terminal morphology is simple compared to controls
• spindle development fails to progress beyond E18 and mature spindles do not form
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• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls
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• innervation of muscle spindles is simpler than observed in controls, but spindle afferent projection to the ventral spinal cord shows normal pattern
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• monosynaptic inputs from muscle spindle afferent to motor neurons are functional but reduced in amplitude; EPSPs evoked by dorsal root stimulation or evoked by muscle nerve stimulation are reduced from those of controls by similar amounts (to about 22-26% of wild-type amplitudes)
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muscle
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• only rudimentary muscle spindles with a single Egr3-positive myofiber are seen in tibialis anterior muscles at P3 in contrast to spindles in controls which have multiple Egr3+ intrafusal myofibers
• on P4 muscle spindles, few mutant spindles have the complex annulospiral afferent terminal seen around the equatorial region of intrafusal myofibers in control muscle; muscle spindle afferent terminal morphology is simple compared to controls
• spindle development fails to progress beyond E18 and mature spindles do not form
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• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
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• death between 3 and 8 weeks of age
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digestive/alimentary system
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• mutants exhibit a constricted distal colon and a distended proximal colon
• mutants show an increase in the number of apoptotic cells in the myenteric layer of the colon, but no difference in apoptosis in the mucosa
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growth/size/body
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• starting at 2 weeks after birth, mutants become noticeably smaller than controls
• mutants are often less than half the size of controls at time of death
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• starting at 2 weeks after birth, mutants become noticeably smaller than controls
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nervous system
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• loss of enteric glia in the colon by 3-4 weeks of age
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• progressive postnatal loss of enteric neurons in the colon but not the intestine, such that there is a 55% decrease in enteric neurons at P24
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Tg(Mpz-cre)1Brn mutation
(1 available)
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normal phenotype
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• mutants are indistinguishable from controls and do not show loss of enteric neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Klee mutation
(0 available);
any
Erbb2 mutation
(59 available)
Tg(Ckmm-cre)1Lrsn mutation
(0 available)
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cardiovascular system
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• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged
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|
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• increase in apoptosis in the ventricles
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|
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• decrease in LV septal thickness
|
|
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• decrease in LV posterior ventricular wall thickness
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• all mutants develop dilated cardiomyopathy by 6 weeks of age
• exhbiit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio
|
|
|
• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure
|
|
|
• reduction in left ventricle dP/dtmin indicates impaired left ventricle relaxation
|
muscle
|
|
• increase in the numbers of mitochondria and vacuoles in cardiomyoctyes, however cytoskeletal ultrastructure is unchanged
|
|
|
• all mutants develop dilated cardiomyopathy by 6 weeks of age
• exhbiit ventricular enlargement of both the left and right cardiac chambers and a marked increase in heart:body weight ratio
|
|
|
• decrease in fractional shortening, velocity of circumferential fiber shortening and a reduction of the maximum first derivative of left ventricle pressure, indicating depressed myocardium contractility, however no differences in heart rate or left ventricle end-diastolic pressure
|
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• reduction in left ventricle dP/dtmin indicates impaired left ventricle relaxation
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Analysis Tools