Phenotypes associated with this allele

• Allele Symbol: Skil^tm1Sis
• Allele Name: targeted mutation 1, Shunsuke Ishii
• Allele ID: MGI:2387096
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Skil^tm1Sis/Skil^tm1Sis	involves: C57BL/6 * CBA	MGI:2671693
ht2	Skil^tm1Sis/Skil^+	involves: C57BL/6 * CBA	MGI:2671719

Genotype
MGI:2671693

hm1

• Allelic Composition: Skil^tm1Sis/Skil^tm1Sis
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:62174 )

• no homozygous embryos found after E3.5

embryo

failure of zygotic cell division ( J:62174 )

• in vitro failure of embryos to divide after 16 cell stage or to form blastocoel

Genotype
MGI:2671719

ht2

• Allelic Composition: Skil^tm1Sis/Skil⁺
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:62174 )

• only 56.5% of female mice and 42.9% of male mice survive 9,10-dimethyl-1,2-benzanthracene (DMBA) exposure and remain tumor free

neoplasm

increased T cell derived lymphoma incidence ( J:62174 )

• one individual with tumors of the spleen

• no tumors were seen in 220 wild-type mice in the same colony

increased incidence of tumors by chemical induction ( J:62174 )

• exposure to 9,10-dimethyl-1,2-benzanthracene (DMBA) results in increased incidence of malignant lymphomas in heterozygous mice

increased B cell derived lymphoma incidence ( J:62174 )

• one individual with tumors of the pancreas

• no tumors were seen in 220 wild-type mice in the same colony

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:62174 )

• only 56.5% of female mice and 42.9% of male mice survive 9,10-dimethyl-1,2-benzanthracene (DMBA) exposure and remain tumor free

increased incidence of tumors by chemical induction ( J:62174 )

• exposure to 9,10-dimethyl-1,2-benzanthracene (DMBA) results in increased incidence of malignant lymphomas in heterozygous mice

growth/size/body

cachexia ( J:62174 )

• severe wasting after 4 months of age in 2 out of 104 mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:62174 )

• one individual with tumors of the spleen

• no tumors were seen in 220 wild-type mice in the same colony